Treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes using menthol, linalool and/or icilin

Abstract

Compositions for prevention or treatment of non-inflammatory neuronal damage from brain trauma and strokes are provided, and the compositions contain a therapeutically effective amount of a compound selected from the group consisting of Menthol, Linalool, Icilin and combinations thereof. Methods for treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes are also provided, and the methods include administering such compositions.

1 . A method for treating non-inflammatory neuronal damage from a condition selected from the group consisting of brain trauma, a stroke and a combination thereof, comprising administering to an individual having such damage a composition comprising a therapeutically effective amount of a compound selected from the group consisting of Menthol, Linalool, Icilin and combinations thereof. 
     
     
         2 . The method of  claim 1  wherein the composition is selected from the group consisting of a medicament, a food product and a supplement to a food product. 
     
     
         3 . A method for preventing non-inflammatory neuronal damage from a condition selected from the group consisting of brain trauma, a stroke and a combination thereof, comprising administering to an individual having the condition a composition comprising a therapeutically effective amount of a compound selected from the group consisting of Menthol, Linalool, Icilin and combinations thereof. 
     
     
         4 . The method of  claim 3  wherein the composition is selected from the group consisting of a medicament, a food product and a supplement to a food product. 
     
     
         5 . A method for preventing non-inflammatory neuronal apoptosis from a condition selected from the group consisting of brain trauma, a stroke and a combination thereof, comprising administering to an individual a composition comprising a therapeutically effective amount of a compound selected from the group consisting of Menthol, Linalool, Icilin and combinations thereof. 
     
     
         6 . The method of  claim 5  wherein the composition is selected from the group consisting of a medicament, a food product and a supplement to a food product. 
     
     
         7 . A method for preventing non-inflammatory neuronal necrosis from a condition selected from the group consisting of brain trauma, a stroke and a combination thereof, comprising administering to an individual having the condition a composition comprising a therapeutically effective amount of a compound selected from the group consisting of Menthol, Linalool, Icilin and combinations thereof. 
     
     
         8 . The method of  claim 7  wherein the composition is selected from the group consisting of a medicament, a food product and a supplement to a food product. 
     
     
         9 . A method for providing neuroprotection to an individual in need of same comprising administering a composition comprising a therapeutically effective amount of a compound selected from the group consisting of Menthol, Linalool, Icilin and combinations thereof. 
     
     
         10 . The method of  claim 9  wherein the composition is a medicament. 
     
     
         11 . The method of  claim 9  wherein the composition is a food product. 
     
     
         12 . The method of  claim 11  wherein the food product comprises a component selected from the group consisting of protein, carbohydrate, fat and combinations thereof. 
     
     
         13 . The method of  claim 9  wherein the composition is a supplement to a food product.