Cyclooxygenase Inhibitor and Calcium Channel Antagonist Compositions and Methods for Use in Urological Procedures

Abstract

Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the urinary tract during urological diagnostic, interventional, surgical and other medical procedures. One disclosed composition comprises ketoprofen and nifedipine in a liquid irrigation carrier, and includes a solubilizing agent, stabilizing agents and a buffering agent.

1 .- 11 . (canceled) 
     
     
         12 . A method of inhibiting pain/inflammation and spasm in the urinary tract, comprising:
 delivering to the urinary tract a composition including a combination of ketoprofen and a calcium channel antagonist in a carrier, each of the ketoprofen and the calcium channel antagonist included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm in the urinary tract.   
     
     
         13 . The method of  claim 12 , wherein the composition is delivered periprocedurally to the urinary tract during a urological diagnostic, interventional, surgical and other medical procedure. 
     
     
         14 . The method of  claim 13 , wherein the composition is periprocedurally delivered during a cystoscopic procedure. 
     
     
         15 . The method of  claim 13 , wherein the composition is periprocedurally delivered during a ureteroscopic procedure. 
     
     
         16 . The method of  claim 13 , wherein the composition is periprocedurally delivered during a procedure to remove, fragment or dislodge a kidney or bladder stone. 
     
     
         17 . The method of  claim 13 , wherein the composition is periprocedurally delivered during a procedure that causes thermal injury to urinary tract tissue. 
     
     
         18 . The method of  claim 17 , wherein the composition is periprocedurally delivered during a laser, microwave ablation, radiofrequency ablation, electrocauterization or cryoblation procedure. 
     
     
         19 . The method of  claim 13 , wherein the composition is periprocedurally delivered during a transurethral resection of a prostate. 
     
     
         20 . The method of  claim 12 , wherein the calcium channel antagonist in the composition comprises nifedipine. 
     
     
         21 . A method of inhibiting pain/inflammation and spasm in the urinary tract during a diagnostic, interventional, surgical or other medical urological procedure, comprising:
 periprocedurally delivering to the urinary tract during a urological procedure a composition including a combination of ketoprofen and nifedipine in a carrier, each of the ketoprofen and the nifedipine included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm in the urinary tract.   
     
     
         22 . The method of  claim 21 , wherein the composition is during a cystoscopic procedure. 
     
     
         23 . The method of  claim 21 , wherein the composition is periprocedurally delivered during a ureteroscopic procedure. 
     
     
         24 . The method of  claim 21 , Wherein the composition is periprocedurally delivered during a procedure to remove, fragment or dislodge a kidney or bladder stone. 
     
     
         25 . The method of  claim 21 , wherein the composition is periprocedurally delivered during a procedure that causes thermal injury to urinary tract tissue. 
     
     
         26 . The method of  claim 25 , wherein the composition is periprocedurally delivered during a laser, microwave ablation, radiofrequency ablation, electrocauterization or cryoblation procedure. 
     
     
         27 . The method of  claim 21 , wherein the composition is periprocedurally delivered during a transurethral resection of a prostate. 
     
     
         28 . The method of  claim 21 , wherein the composition is periprocedurally delivered transrectally or transperitoneally to the prostate. 
     
     
         29 . A method of inhibiting pain/inflammation and spasm in the urinary tract during a urological procedure, comprising:
 periprocedurally delivering to the urinary tract during a ureteroscopic procedure a composition including a combination of a cyclooxygenase inhibitor and a calcium channel antagonist in a carrier, each of the cyclooxygenase inhibitor and the calcium channel antagonist included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm in the urinary tract.   
     
     
         30 . The method of  claim 29 , wherein the cyclooxygenase (COX) inhibitor in the composition comprises a nonselective COX-1/COX-2 inhibitor. 
     
     
         31 . A method of inhibiting pain/inflammation and spasm in the urinary tract during a urological procedure, comprising:
 periprocedurally delivering to the urinary tract during a procedure to remove, fragment or dislodge a kidney or bladder stone a composition including a combination of a cyclooxygenase inhibitor and a calcium channel antagonist in a carrier, each of the cyclooxygenase inhibitor and the calcium channel antagonist included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm in the urinary tract.   
     
     
         32 . The method of  claim 31 , wherein the cyclooxygenase (COX) inhibitor in the composition comprises a nonselective COX-1/COX-2 inhibitor. 
     
     
         33 . A method of inhibiting pain/inflammation and spasm in the urinary tract during a urological procedure, comprising:
 periprocedurally delivering to the urinary tract during a procedure that causes thermal injury to urinary tract tissue a composition including a combination of a cyclooxygenase inhibitor and a calcium channel antagonist in a carrier, each of the cyclooxygenase inhibitor and the calcium channel antagonist included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm in the urinary tract.   
     
     
         34 . The method of  claim 33 , wherein the cyclooxygenase (COX) inhibitor in the composition comprises a nonselective COX-1/COX-2 inhibitor. 
     
     
         35 . The method of  claim 34 , wherein the composition is delivered periprocedurally to the urologic structure during a laser, microwave ablation, radiofrequency ablation, electrocauterization or cryoblation procedure. 
     
     
         36 . A method of inhibiting pain/inflammation and spasm during a urological procedure, comprising:
 periprocedurally delivering transrectally or transperitoneally to the prostate a composition including a combination of a cyclooxygenase inhibitor and a calcium channel antagonist in a carrier, each of the cyclooxygenase inhibitor and the calcium channel antagonist included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm.   
     
     
         37 . The method of  claim 36 , wherein the cyclooxygenase (COX) inhibitor in the composition comprises a nonselective COX-1/COX-2 inhibitor. 
     
     
         38 . A method of inhibiting pain, inflammation and/or spasm in the urinary tract during a urological procedure, comprising:
 periprocedurally delivering to the urinary tract during a ureteroscopic procedure a composition including a combination of a plurality of agents that inhibit pain/inflammation and/or spasm in a carrier, each agent included in a therapeutically effective amount such that the combination inhibits pain/inflammation and/or spasm in the urinary tract.   
     
     
         39 . A method of inhibiting pain, inflammation and/or spasm in the urinary tract during a urological procedure, comprising:
 periprocedurally delivering to the urinary tract during a procedure to remove, fragment or dislodge a kidney or bladder stone a composition including a combination of a plurality of agents that inhibit pain/inflammation and/or spasm in a carrier, each agent included in a therapeutically effective amount such that the combination inhibits pain/inflammation and/or spasm in the urinary tract.   
     
     
         40 . A method of inhibiting pain, inflammation and/or spasm in the urinary tract during a urological procedure, comprising:
 periprocedurally delivering to the urinary tract during a procedure that causes thermal injury to urinary tract tissue a composition including a combination of a plurality of agents that inhibit pain/inflammation and/or spasm in a carrier, each agent included in a therapeutically effective amount such that the combination inhibits pain/inflammation and/or spasm in the urinary tract.   
     
     
         41 . The method of  claim 40 , wherein the composition is delivered periprocedurally to the urologic structure during a laser, microwave ablation, radiofrequency ablation, electrocauterization or cryoblation procedure. 
     
     
         42 . A method of inhibiting pain, inflammation and/or spasm during a urological procedure, comprising:
 periprocedurally delivering transrectally or transperitoneally to the prostate a composition including a combination of a plurality of agents that inhibit pain/inflammation and/or spasm in a carrier, each agent included in a therapeutically effective amount such that the combination inhibits pain/inflammation and/or spasm.