US2016166550A1PendingUtilityA1
Combination Therapies for the Treatment of Alzheimer's Disease and Related Disorders
Est. expiryOct 25, 2032(~6.3 yrs left)· nominal 20-yr term from priority
Inventors:David R. Elmaleh
A61P 43/00A61P 25/28A61P 29/00A61P 25/00A61P 17/02A61K 31/047C07K 16/18A61K 31/075A61K 48/00A61K 31/706A61K 39/0005A61K 45/06A61K 31/225A61K 38/185A61K 31/5415A61K 31/438A61K 31/13A61K 31/428A61K 31/55A61K 51/0453A61K 31/713A61K 31/435A61K 31/353A61K 31/194A61K 31/352A61K 31/192
65
PatentIndex Score
0
Cited by
0
References
0
Claims
Abstract
The present invention relates to combination therapies for treating Alzheimer's disease or an amyloidosis-associated pathological condition comprising co-administering a therapeutically effective amount of a first compound, and a therapeutically effective amount of a second compound. In certain embodiments, the first compound or the second compound inhibits AB peptide polymerization; is an anti-inflammatory; improves cognitive function, mood, or social behavior; is associated with Tau or alpha-synuclein; or regulates amyloid peptide washout.
Claims
exact text as granted — not AI-modified1 - 20 . (canceled)
21 . A method of treating a disease or condition in a subject in need thereof comprising co-administering a therapeutically effective amount of a first compound, and a therapeutically effective amount of a second compound, wherein the disease or condition is Alzheimer's disease, dementia, an amyloidosis-associated condition, or a head injury.
22 . A method of slowing the progression of a disease or condition in a subject in need thereof comprising co-administering a therapeutically effective amount of a first compound, and a therapeutically effective amount of a second compound, wherein the disease or condition is Alzheimer's disease, dementia, an amyloidosis-associated condition, or a head injury.
23 . The method of claim 21 , wherein at least one of the first compound and the second compound is a compound inhibiting Aβ peptide polymerization, and the compound inhibiting Aβ peptide polymerization is selected from the group consisting of formula I-IV:
wherein, independently for each occurrence,
R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are hydrogen, halo, azido, alkyl, haloalkyl, perhaloalkyl, fluoroalkyl, perfluoroalkyl, aralkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteroaralkyl, hydroxy, alkoxy, aryloxy, heteroaryloxy, aralkyloxy, heteroaralkyloxy, amino, alkylamino, arylamino, acylamino, heteroarylamino, nitro, sulfhydryl, imino, amido, phosphonate, phosphinate, acyl, carboxyl, oxycarbonyl, acyloxy, silyl, thioether, sulfo, sulfonate, sulfonyl, sulfonamido, formyl, cyano, isocyano, or —Y-(haloalkylene)-alkyl;
R 7 is hydrogen, halo, azido, alkyl, haloalkyl, perhaloalkyl, fluoroalkyl, perfluoroalkyl, aralkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteroaralkyl, hydroxy, alkoxy, aryloxy, heteroaryloxy, aralkyloxy, heteroaralkyloxy, amino, alkylamine, arylamino, acylamino, heteroarylamino, nitro, sulfhydryl, imino, amido, phosphonate, phosphinate, acyl, carboxyl, oxycarbonyl, acyloxy, silyl, thioether, sulfo, sulfonate, sulfonyl, sulfonamide, formyl, cyano, isocyano, —Y-(haloalkylene)-alkyl, or —Y-(haloalkylene)-R;
R N is hydrogen, lower alkyl, or -(haloalkylene)-alkyl;
Y is a bond, N(R N ), O, or S; and
R is
provided that at least one of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , or R 10 is —Y-(haloalkylene)-alkyl; or R N is -(haloalkylene)-alkyl.
24 . The method of claim 22 , wherein at least one of the first compound and the second compound is a compound inhibiting Aβ peptide polymerization, and the compound inhibiting Aβ peptide polymerization is selected from the group consisting of formula I-IV:
wherein, independently for each occurrence,
R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are hydrogen, halo, azido, alkyl, haloalkyl, perhaloalkyl, fluoroalkyl, perfluoroalkyl, aralkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteroaralkyl, hydroxy, alkoxy, aryloxy, heteroaryloxy, aralkyloxy, heteroaralkyloxy, amino, alkylamino, arylamino, acylamino, heteroarylamino, nitro, sulfhydryl, imino, amido, phosphonate, phosphinate, acyl, carboxyl, oxycarbonyl, acyloxy, silyl, thioether, sulfo, sulfonate, sulfonyl, sulfonamido, formyl, cyano, isocyano, or —Y-(haloalkylene)-alkyl;
R 7 is hydrogen, halo, azido, alkyl, haloalkyl, perhaloalkyl, fluoroalkyl, perfluoroalkyl, aralkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteroaralkyl, hydroxy, alkoxy, aryloxy, heteroaryloxy, aralkyloxy, heteroaralkyloxy, amino, alkylamine, arylamino, acylamino, heteroarylamino, nitro, sulfhydryl, imino, amido, phosphonate, phosphinate, acyl, carboxyl, oxycarbonyl, acyloxy, silyl, thioether, sulfo, sulfonate, sulfonyl, sulfonamide, formyl, cyano, isocyano, —Y-(haloalkylene)-alkyl, or —Y-(haloalkylene)-R;
R N is hydrogen, lower alkyl, or -(haloalkylene)-alkyl;
Y is a bond, N(R N ), O, or S; and
R is
provided that at least one of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , or R 10 is —Y-(haloalkylene)-alkyl; or R N is -(haloalkylene)-alkyl.
25 . The method of any of claim 23 , the compound inhibiting Aβ peptide polymerization is
26 . The method of any of claim 25 , the compound inhibiting Aβ peptide polymerization is
27 . The method of any of claim 24 , the compound inhibiting Aβ peptide polymerization is
28 . The method of any of claim 27 , the compound inhibiting Aβ peptide polymerization isJoin the waitlist — get patent alerts
Track US2016166550A1 — get alerts on status changes and closely related new filings.
We store only your email — no account needed. See our privacy policy.