US2016159879A1PendingUtilityA1

Regulation of sodium channels by plunc proteins

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Assignee: UNIV NORTH CAROLINAPriority: Sep 20, 2011Filed: Dec 16, 2015Published: Jun 9, 2016
Est. expirySep 20, 2031(~5.2 yrs left)· nominal 20-yr term from priority
Inventors:Robert TarranMonroe Jack StuttsScott Donaldson
A61P 1/00A61P 11/06A61K 38/00C07K 14/435C07K 14/705C07K 7/08
37
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Claims

Abstract

The present invention relates to the ability of PLUNC proteins, such as SPLUNC1 and SPLUNC2, to bind to sodium channels and inhibit activation of the sodium channels. The invention further relates to methods for regulating of sodium absorption and fluid volume and treating disorders responsive to modulating sodium absorption by modulating the binding of PLUNC proteins to sodium channels.

Claims

exact text as granted — not AI-modified
1 . A polypeptide consisting essentially of the sodium channel binding domain of a PLUNC protein, or a functional fragment or homolog thereof. 
     
     
         2 - 47 . (canceled)

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