Method for inhibiting cell growth using anti-erbb-3 antibodies

Abstract

Methods for arresting or inhibiting cell growth, particularly cancer cell growth, comprising preventing or reducing ErB-2/ErbB-3 heterodimer formation, or interfering with ErB-2/ErbB-3 heterodimer conformation in a cell and agents which prevent or reduce ErB-2/ErbB-3 heterodimer formation or interface with ErB-2/ErbB-3 heterodimer conformation in a cell thereby arresting or inhibiting the growth of the cell.

1 - 26 . (canceled) 
     
     
         27 . A method of arresting or inhibiting cell growth comprising contacting an ErbB-2 over-expressing cell with an anti-ErbB-3 antibody, thereby arresting or inhibiting growth of said ErbB-2 over-expressing cell. 
     
     
         28 . The method of  claim 27 , wherein the anti-ErbB-3 antibody is H3.105.5. 
     
     
         29 . The method of  claim 27 , wherein the anti-ErbB-3 antibody is a monoclonal antibody. 
     
     
         30 . The method of  claim 29 , wherein the monoclonal antibody is humanized. 
     
     
         31 . The method of  claim 27 , wherein the cell is a cancer cell. 
     
     
         32 . The method of  claim 31 , wherein the cancer cell is a human breast cancer cell. 
     
     
         33 . The method of  claim 32 , wherein the human breast cancer cell is SK-BR-3, MDA-MB-453, or BT-474. 
     
     
         34 . A method for treating ErbB-2 over-expressing cancer, comprising administering to a subject in need thereof a composition comprising an anti-ErbB-3 antibody, thereby treating ErbB-2 over-expressing cancer in said subject. 
     
     
         35 . The method of  claim 34 , wherein the anti-ErbB-3 antibody is H3.105.5. 
     
     
         36 . The method of  claim 34 , wherein the anti-ErbB-3 antibody is a monoclonal antibody. 
     
     
         37 . The method of  claim 36 , wherein the monoclonal antibody is humanized. 
     
     
         38 . The method of  claim 34 , wherein the cancer is a human breast cancer.