Methods of use of biomaterial and injectable implant containing biomaterial

Abstract

This invention relates to the use of a biomaterial for the treatment, repair and/or enhancement of bodily tissue insufficiencies of the vocal chords, muscles, ligaments, cartilage, post-operative regions, sexual organs and/or weight supporting areas of the feet as well as other conditions of the bones and joints. The biomaterial for use in the invention may comprise an injectable bioresorbable polysaccharide composition wherein the polysaccharide may be succinochitosan glutamate. This invention also relates to the use of a biomaterial comprising an injectable bioresorbable polysaccharide composition in which resorbable particles may be in suspension, the said particles comprising or consisting essentially of chitin. and/or chitosan, which may be free of any additional formulation modifying agents, and a process for manufacturing the same. The invention also includes the use of various medicaments in the biomaterial formulations to enhance the treatment of the affected area of the body.

1 . A method of treating and/or repairing vocal chords comprising administering a composition to the vocal chords or surrounding tissue, wherein said composition is in the form of a gel comprising an injectable. bioresorbable polysaccharide, and wherein said composition further comprises resorbable particles which are in suspension in said gel, the said particles comprising chitin and/or chitosan. 
     
     
         2 . The method according to  claim 1 , wherein the injectable bioresorbable polysaccharide is chitosan, or a derivative thereof, having a degree of deacetylation of about 30 to about 95%. 
     
     
         3 . The method according to  claim 1 , wherein the injectable bioresorbable polysaccharide is succinochitosan glutamate. 
     
     
         4 . The method according to  claim 1 , wherein the composition comprises, about 0.1 to about 20% chitosan, or a derivative thereof, as the injectable bioresorbable polysaccharide. 
     
     
         5 . The method according to  claim 1 , wherein the weight percent of resorbable particles in the composition is between about 0.1% and about 10% by total weight of the composition. 
     
     
         6 . The method according to  claim 1 , wherein the resorbable particles consist essentially of chitin. 
     
     
         7 . The method according to  claim 1 , wherein the composition contains one or more medicaments selected from the group of: anesthetics, anti-inflammatories, analgesics, antimicrobials, antibiotics or growth factors.