Modulators of atp-binding cassette transporters

Abstract

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

1 - 69 . (canceled) 
     
     
         70 . A method of treating or lessening the severity of cystic fibrosis in a patient in need of the treatment comprising administering to the patient in need of the treatment an effective amount of a pharmaceutical composition, wherein the pharmaceutical composition comprises:
 (i) a compound of the formula:   
       
         
           
           
               
               
           
         
       
       and/or a pharmaceutically acceptable salt thereof;
 (ii) a pharmaceutically acceptable carrier; and 
 (iii) a compound of the formula: 
 
       
         
           
           
               
               
           
         
       
       and/or a pharmaceutically acceptable salt thereof.