Compositions And Method For Treatment Of Ischemic Neuronal Reperfusion Injury

Abstract

A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition can include a compound which is a combination of dantrolene and a residue of FMOC-valine. This composition can be used to provide a faster and higher CNS penetration than heretofore experienced with dantrolene. In another form, dantrolene may be formulated as a pro-drug, a pro-pro-drug and the like.

1 .- 18 . (canceled) 
     
     
         19 . A method of treatment of neuronal reperfusion injury with ischemic neuropathy, the method comprising:
 administering an effective amount of at least one compound selected from the group consisting of a pro-drug form of dantrolene, a pro-pro-drug form of dantrolene, and mixtures thereof.   
     
     
         20 . The method of  claim 19  wherein the step of administering is performed intranasally using a positive pulsating pressure with pulses occurring about every 5 seconds to 3 minutes. 
     
     
         21 . The method of  claim 19  wherein the at least one compound is in the form of nanoparticles. 
     
     
         23 . The method of  claim 19  wherein the at least one compound is administered via a nebulizer. 
     
     
         24 . The method of  claim 19  wherein the at least one compound is administered in combination with at least one of Vitamin D, Vitamin E, and pluronic acid. 
     
     
         25 . The method of  claim 19  wherein the at least one compound is in the form of a suspension or emulsion. 
     
     
         26 . The method of  claim 19  wherein the at least one compound is delivered to a patient via an administration selected from the group consisting of orally, subcutaneously, parenterally, intravenously, intranasally, intrathecally, sublingually, rectally, and topically. 
     
     
         27 . The method of  claim 19  wherein the at least one compound is administered in a dosage of about 100 ng/kg per day to about 100 mg/kg per day. 
     
     
         28 . A gas mask which includes at least one of a compound being deliverable to a wearer, the compound selected from the group consisting of a pro-drug form of dantrolene, a pro-pro-drug form of dantrolene, and mixtures thereof. 
     
     
         29 . The gas mask of  claim 28  further comprising at least one of Vitamin D, Vitamin E, and pluronic acid in combination with the compound. 
     
     
         30 . The gas mask of  claim 28  wherein the compound is in the form of a suspension or emulsion. 
     
     
         31 . The gas mask of  claim 28  wherein the at least one compound is in the form of nanoparticles. 
     
     
         32 . A method of protecting a human from a nerve gas, the method comprising administering at least one of a compound through the lungs or intranasally, the compound selected from the group consisting of a pro-drug form of dantrolene, a pro-pro-drug form of dantrolene, and mixtures thereof. 
     
     
         33 . The method of  claim 32  wherein the step of administering is performed intranasally using a positive pulsating pressure with pulses occurring about every 5 seconds to 3 minutes. 
     
     
         34 . The method of  claim 32  wherein the at least one compound is in the form of nanoparticles. 
     
     
         35 . The method of  claim 32  wherein the at least one compound is administered via a nebulizer. 
     
     
         36 . The method of  claim 32  wherein the at least one compound is administered in combination with at least one of Vitamin D, Vitamin E, and pluronic acid. 
     
     
         37 . The method of  claim 32  wherein the at least one compound is in the form of a suspension or emulsion.