Biomarkers for seizures

Abstract

The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood plasma or blood serum of a mammalian subject. Also provided are methods for detecting seizure, methods for predicting seizure, use of sICAM-5 in the treatment of seizure, methods for assessing the effectiveness of a treatment of seizure, and diagnostic kits.

1 . A method for predicting or detecting seizure in a mammalian subject comprising:
 contacting a blood plasma or blood serum sample obtained from a mammalian subject with a diagnostic reagent that can measure or detect the expression level of soluble ICAM-5 (sICAM-5); and   contacting said blood plasma or blood serum sample obtained from a mammalian subject with a diagnostic reagent that can measure or detect the expression level of TARC;   wherein a decreased plasma or serum concentration of sICAM-5 in said blood plasma or blood serum sample of said mammalian subject, in combination with an increased plasma or serum concentration of TARC in said blood plasma or blood serum sample of said mammalian subject, indicates a tendency to have seizure.