Ketoprofen-Containing Aqueous Adhesive Skin Patch

Abstract

Provided is a water-based patch that contains ketoprofen as an active ingredient, provides high transdermal absorbability of the ketoprofen, and has high safety and high storage stability. The water-based patch contains the ketoprofen, an amine, and polyethylene glycol. In the water-based patch, the added amount of the ketoprofen in a paste is 0.1 to 5% by weight, the added amount of the amine in the paste is 0.5 to 10% by weight, and the added amount of the polyethylene glycol in the paste is 5 to 30% by weight. Particularly, in the water-based patch, diisopropanolamine is used as the amine.

1 . A water-based patch comprising a paste comprising a ketoprofen, an amine as a solubilizing agent for the ketoprofen, and polyethylene glycol as an esterification inhibitor for the ketoprofen, wherein the amount of the ketoprofen in the paste is 0.1 to 5% by weight, the amount of the amine in the paste is 0.5 to 10% by weight, and the amount of the polyethylene glycol in the paste is 5 to 30% by weight. 
     
     
         2 . The water-based patch according to  claim 1 , wherein diisopropanolamine is used as the amine. 
     
     
         3 . A water-based patch comprising a paste comprising: (a) a ketoprofen, (b) an amine as a solubilizing agent for the ketoprofen, and (c) polyethylene glycol as an esterification inhibitor for the ketoprofen,
 wherein the amount of the ketoprofen in the paste is 0.1 to 5% by weight, the amount of the amine in the paste is 0.5 to 10% by weight, and the amount of the polyethylene glycol in the paste is 5 to 30% by weight,   wherein the paste is prepared by the steps of:
 (1) solubilizing the ketoprofen in the amine to form a solubilized ketoprofen, 
 (2) preparing a hydrated gel comprising the polyethylene glycol in water, and 
 (3) mixing the solubilized ketoprofen into the hydrated gel uniformly to generate a paste.