Treatment simulator for brain diseases and method of use thereof

Abstract

A treatment simulator for providing information on physiological states and effects of treatment of neurological disease, comprising a computer, and an application configured to operate with the computer. The application is capable of: obtaining radiological imaging from the brain; obtaining anatomical information from the radiological imaging within a region of interest within the brain; constructing a physiological states model which assesses physiological states of the region of interest; locating sources of interstitial flow of particulate matter and obtaining fluid conductivities of paths of the interstitial flow utilizing the anatomical information and the physiological states model; and creating a flow model of the particulate matter which assesses velocities of flow and interstitial pressure variations utilizing the sources of interstitial flow and the fluid conductivities.

1 . A method for providing information regarding administration of a chemotherapy treatment for neurological disease in a patient, comprising:
 obtaining radiological imaging from the brain of the patient following systemic administration of an agent into the brain;   obtaining serum concentration level information of the agent;   determining central nervous system tissue concentration level information of the agent, the tissue concentration level information accounting for blood-brain barrier state information, chemical property information, and physical property information of the agent;   obtaining other physiological information from radiological imaging and/or clinical data;   displaying the radiological imaging, the serum concentration level information, the tissue concentration level information, or the other physiological information, or any combination thereof, in a chemotherapy model.   
     
     
         2 . The method of  claim 1 , wherein the tissue concentration level information is displayed as: a 2-dimensional illustration, a 3-dimensional illustration, an intensity illustration, a color-coded illustration, a static illustration, or a dynamically altering (with time) illustration, or any combination thereof. 
     
     
         3 . The method of  claim 1 , further comprising:
 making available the tissue concentration level information for data analysis.   
     
     
         4 . The method of  claim 1 , wherein the chemotherapy model also takes into account retrospective data on the behavior of the agent. 
     
     
         5 . A system for providing information regarding administration of treatment for neurological disease in a patient, comprising:
 a server coupled to a network;   a user terminal coupled to the network;   an application coupled to the server and/or the user terminal, wherein the application is configured for:   obtaining radiological imaging from the brain of the patient following systemic administration of an agent into the brain;   obtaining serum concentration level information of the agent;   determining central nervous system tissue concentration level information of the agent, the tissue concentration level information accounting for blood-brain barrier state information, chemical property information, and physical property information of the agent;   obtaining other physiological information from radiological imaging and/or clinical data;   displaying the radiological imaging, the serum concentration level information, the tissue concentration level information, or the other physiological information, or any combination thereof, in a chemotherapy model.   
     
     
         6 . The system of  claim 5 , wherein the tissue concentration level information is displayed as: a 2-dimensional illustration, a 3-dimensional illustration, an intensity illustration, a color-coded illustration, a static illustration, or a dynamically altering (with time) illustration, or any combination thereof. 
     
     
         7 . The system of  claim 5 , wherein the application is further configured for:
 making available the tissue concentration level information for data analysis.   
     
     
         8 . The system of  claim 5 , wherein the chemotherapy model also takes into account retrospective data on the behavior of the agent. 
     
     
         9 . A method for providing a representation and display of brain physiological information, comprising:
 obtaining radiological imaging correlates of a physiological state of the brain;   obtaining a constitutive property of the brain;   constructing a network representation of the constitutive property and any corresponding flow; and   displaying the network representation with the radiological imaging as a pseudo-channel model.   
     
     
         10 . The method of  claim 9 , wherein the constitutive property includes a transport property, a tensor, capacity, or any combination thereof. 
     
     
         11 . The method of  claim 9 , wherein the pseudo-channel model is a network representation of three dimensional curves joining nodes. 
     
     
         12 . The method of  claim 9 , wherein the constitutive property is color coded. 
     
     
         13 . The method of  claim 9 , wherein the pseudo-channel model can be updated and displayed in real time as a user inputs additional information. 
     
     
         14 . A system for providing a representation and display of brain physiological information, comprising:
 a server coupled to a network;   a user terminal coupled to the network;   an application coupled to the server and/or the user terminal, wherein the application is configured for:   obtaining radiological imaging correlates of a physiological state of the brain;   obtaining a constitutive property of the brain;   constructing a network representation of the constitutive property and any corresponding flow; and   displaying the network representation with the radiological imaging as a pseudo-channel model.   
     
     
         15 . The system of  claim 14 , wherein the constitutive property includes a transport property, a tensor, capacity, or any combination thereof. 
     
     
         16 . The system of  claim 14 , wherein the pseudo-channel model is a network representation of three dimensional curves joining nodes. 
     
     
         17 . The system of  claim 14 , wherein the constitutive property is color coded. 
     
     
         18 . The system of  claim 14 , wherein the pseudo-channel model can be updated and displayed in real time as a user inputs additional information.