Inhibitors of hepatitis c virus

Abstract

Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

What is claimed is: 
     
         1 . A compound of Formula (IV): 
       
         
           
           
               
               
           
         
         or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein: 
         J is C 1 -C 4  alkyl or C 3 -C 6  carbocyclyl, wherein the C 1 -C 4  alkyl or C 3 -C 6  carbocyclyl is optionally substituted with 1-4 halogen, —OH, aryl or cyano; 
         {circle around (T)} is C 3 -C 5  carbocyclylene that is attached to L and to the remainder of the compound of Formula IV through two adjacent carbons, wherein said C 3 -C 5  carbocyclylene is optionally substituted with C 1 -C 4  alkyl, C 1 -C 3  haloalkyl, halogen, —OH, or cyano, or {circle around (T)} is C 5 -C 8  bicyclic carbocyclylene that is attached to L and to the remainder of the compound of Formula IV through two adjacent carbons, or C 3 —C 6  carbocyclylene that is attached to L and to the remainder of the compound of Formula IV through two adjacent carbons, wherein said C 3 —O 6  carbocyclene is optionally substituted with C 1 -C 4  alkyl or C 1 -C 3  haloalkyl; 
         L is C 3 -C 6  alkylene, C 3 -C 6  alkenylene or —(CH 2 ) 3 -cyclopropylene-, optionally substituted with 1-4 halogen, —OH, or cyano; 
         Q is C 2 -C 4  alkyl or C 3 -C 6  carbocyclyl optionally substituted with C 1 -C 3  alkyl, halogen, —OH, or cyano; 
         E is C 1 -C 3  alkyl or C 2 -C 3  alkenyl, optionally substituted with 1-3 halogen; 
         W is H, —OH, —O(C 1 -C 3 )alkyl, —O(C 1 -C 3 )haloalkyl, halogen or cyano; and 
         Z 2a  is H or C 1 -C 3  alkyl. 
       
     
     
         2 . The compound of  claim 1 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein J is C 1 -C 3  alkyl. 
     
     
         3 . The compound of  claim 1 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein J is methyl or ethyl. 
     
     
         4 . The compound of any one of  claims 1  to  3 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein {circle around (T)} is C 3 -C 6  carbocyclylene that is attached to L and to the remainder of the compound of Formula IV through two adjacent carbons, wherein said C 3 -C 6  carbocyclene is optionally substituted with C 1 -C 4  alkyl or C 1 -C 3  haloalkyl. 
     
     
         5 . The compound of any one of  claims 1  to  3 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein {circle around (T)} is C 3 -C 6  carbocyclylene that is attached to L and to the remainder of the compound of Formula IV through two adjacent carbons, wherein the C 3 -C 6  carbocyclene is optionally substituted with methyl, ethyl or trifluoromethyl. 
     
     
         6 . The compound of any one of  claims 1  to  3 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein {circle around (T)} is cyclopropylene. 
     
     
         7 . The compound of any one of  claims 1  to  3 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein {circle around (T)} is C 6 -C 8  bridged bicyclic carbocyclylene or C 6 -C 8  fused bicyclic carbocyclylene that is attached to L and to the remainder of the compound of Formula IV through two adjacent carbons. 
     
     
         8 . The compound of any one of  claims 1  to  7 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein L is C 3 -C 6  alkylene, substituted with 1-4 halogens. 
     
     
         9 . The compound of any one of  claims 1  to  7 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein L is C 5  alkylene, substituted with two halogens. 
     
     
         10 . The compound of any one of  claims 1  to  7 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein L is C 3 -C 6  alkylene. 
     
     
         11 . The compound of any one of  claims 1  to  7 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein L is C 5  alkylene. 
     
     
         12 . The compound of  claim 8  or  claim 9 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein the halogens are each fluoro. 
     
     
         13 . The compound of any one of  claims 1  to  12 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein Q is t-butyl or C 5 -C 6  carbocyclyl. 
     
     
         14 . The compound of any one of  claims 1  to  12 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein Q is t-butyl. 
     
     
         15 . The compound of any one of  claims 1  to  14 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein E is C 1 -C 3  alkyl optionally substituted with 1-3 halogen atoms. 
     
     
         16 . The compound of any one of  claims 1  to  14 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein E is difluoromethyl. 
     
     
         17 . The compound of any one of  claims 1  to  16 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein W is hydrogen, —O(C 1 -C 3 )alkyl, halogen or cyano. 
     
     
         18 . The compound of any one of  claims 1  to  16 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein W is methoxy. 
     
     
         19 . The compound of any one of  claims 1  to  18 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein Z 2a  is hydrogen or methyl. 
     
     
         20 . The compound of any one of  claims 1  to  18 , or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein Z 2a  is methyl.