Internal Clamp for Surgical Procedures

Abstract

One aspect of the present invention relates to a method of occluding a vascular site in a mammal comprising the step of introducing into the vasculature of a mammal at or proximal to a surgical site, a composition comprising at least one optionally purified inverse thermosensitive polymer, wherein said inverse thermosensitive polymer gels in said vasculature, thereby temporarily occluding a vascular site of said mammal, wherein said temporarily occluded vasculature site is kept in a substantially cylindrical shape.

What is claimed is: 
     
         1 . A method of occluding a vascular site in a mammal, comprising the steps of:
 (a) introducing into the vasculature of a mammal, at or proximal to a surgical site, a composition comprising at least one purified inverse thermosensitive polymer, wherein said at least one purified inverse thermosensitive polymer gels in said vasculature, thereby temporarily occluding said vascular site of said mammal; and   (b) performing an anastomosis.   
     
     
         2 . The method of  claim 1 , wherein said anastomosis comprises connecting a first vessel and a second vessel, wherein the anastomosis is end-to-end anastomosis, side-to-end anastomosis, and side-to-side anastomosis. 
     
     
         3 . A method of occluding a vascular site in a mammal, comprising the steps of:
 (a) introducing into the vasculature of a mammal, at or proximal to a surgical site, a composition comprising at least one purified inverse thermosensitive polymer, wherein said at least one purified inverse thermosensitive polymer gels in said vasculature, thereby temporarily occluding said vascular site of said mammal; and   (b) performing a surgical procedure comprising anastomosis wherein said anastomosis controls blood oozing.   
     
     
         4 . The method of  claim 1 , wherein said inverse thermosensitive polymer is a poloxamer or poloxamine. 
     
     
         5 . The method of  claim 1 , wherein said inverse thermosensitive polymer is poloxamer 407, poloxamer 338, poloxamer 188, poloxamine 1107 or poloxamine 1307. 
     
     
         6 . A method of occluding a vascular site in a mammal, comprising the steps of:
 (a) introducing into the vasculature of a mammal, at or proximal to a surgical site, a composition comprising at least one purified inverse thermosensitive polymer, wherein said at least one purified inverse thermosensitive polymer gels in said vasculature, thereby temporarily occluding said vascular site of said mammal; and   (b) performing an anastomosis, wherein the inverse thermosensitive polymer is poloxamer 407, poloxamer 338, poloxamer 188, poloxamine 1107 or poloxamine 1307.