Wound dressing sealant and use thereof

Abstract

Embodiments disclosed herein are directed to sealing compositions for negative pressure treatment systems and wound dressing systems, devices containing the same, apparatuses, uses and methods for creating a main wound dressing portion for use in wound care, more particularly for sealing a trimmable dressing, having a main dressing portion or cell in fluid (e.g., gas) communication with additional dressing portions or cells, for use in woundcare, more particularly that may be used for the treatment of wounds. In particular, some embodiments are directed to compositions for improving the versatility of wound dressings for wounds of different shapes or sizes.

1 . A system for treatment of a wound site, the system comprising:
 a dispensable composition for wound care; and   a wound dressing comprising:
 a backing layer having an upper surface and a lower surface and defining a perimeter configured to be positioned over skin surrounding the wound site; 
 one or more transmission layers configured to be positioned below the backing layer; and 
 a port configured to transmit negative pressure through the backing layer for the application of topical negative pressure at the wound site; 
   wherein the wound dressing is configured for removal of a portion of the wound dressing directly enclosing the transmission layer to create a main wound dressing portion with one or more exposed portions wherein the transmission layer is exposed at a portion thereof,   wherein the dispensable composition is configured to form a seal at a location of the one or more exposed portions.   
     
     
         2 - 12 . (canceled) 
     
     
         13 . The system of  claim 1 , wherein the dispensable composition comprises a silicone curing system including one, two or more parts silicone. 
     
     
         14 . (canceled) 
     
     
         15 . The system of  claim 1 , wherein the dispensable composition comprises an RTV-2 silicone curing system. 
     
     
         16 . The system of  claim 1 , wherein the dispensable composition comprises, apportioned between at least one Part A and at least one Part B:
 one or more alkenyl-group containing polymers (i) having at least one alkenyl group or moiety per molecule, one or more SiH-containing polymers (ii) having at least one Si—H unit per molecule;   a catalyst (iii) for curing by addition of alkenyl-containing polymer (i) to SiH-containing polymer (ii);   wherein the dispensable composition cures to an elastomer which is fluid-impermeable at an exposed surface thereof.   
     
     
         17 . The system of  claim 1 , further comprising, for dispensing the dispensable composition, a syringe or static mixer having a nozzle head comprising a spreader tip with plural nozzles. 
     
     
         18 . (canceled) 
     
     
         19 . The system of  claim 1 , wherein the dispensable composition is selected from compounds including siloxanes, modified siloxanes, polyester, polyether urethanes, elastomeric polyether polyesters, polyglycolic acid, ethyl vinyl acetate, polyacrylate, polyacid derivatives of polysaccharides, carboxyalkylcellulose, carboxyalkylchitosan and copolymers thereof, and hybrids of the compounds, the hybrids including copolymers, entangled systems and mixtures thereof. 
     
     
         20 . (canceled) 
     
     
         21 . The system of  claim 1 , further comprising cooperative dispensing device comprising at least one sealed barrel or at least one cassette for a static mixer. 
     
     
         22 - 34 . (canceled) 
     
     
         35 . A method of treating a wound, comprising:
 providing a wound dressing comprising:
 a backing layer; 
 and 
 one or more transmission layers positioned beneath the backing layer; 
   removing a portion of the wound dressing to create a main wound dressing portion with one or more exposed portions, wherein the one or more transmission layers is exposed at the one or more exposed portions;   positioning the main wound dressing portion over a wound;   sealing the main wound dressing portion to skin surrounding the wound; and   dispensing a composition to a location at or within the one or more exposed portions of the main wound dressing portion thereby sealing the one or more exposed portions.   
     
     
         36 . (canceled) 
     
     
         37 . (canceled) 
     
     
         38 . The method of  claim 35 , wherein dispensing the composition comprises internally impregnating the one or more transmission layers at the one or more exposed portions. 
     
     
         39 . (canceled) 
     
     
         40 . (canceled) 
     
     
         41 . The method of  claim 38 , further comprising impregnating the one or more transmission layers to a distance in the range of 0.2 to 25 mm within the one or more transmission layers. 
     
     
         42 . The method of  claim 35 , further comprising applying negative pressure to the wound through the backing layer of the main wound dressing portion. 
     
     
         43 . The method of  claim 42 , further comprising drawing the dispensable composition up to 25 mm within the one or more transmission layers at the one or more exposed portions via the negative pressure. 
     
     
         44 . The method of  claim 42 , wherein the wound dressing exhibits no change or substantially no change in compressibility at the location of the seal on initiation of the negative pressure. 
     
     
         45 . The method of  claim 42 , further comprising dispensing the dispensable composition with formation of an air-tight elastomer which is capable of containing the negative pressure. 
     
     
         46 . The method of  claim 35 , wherein the dispensable composition has a viscosity in the range of 11 and 14 Pa·s. 
     
     
         47 . The method of  claim 35 , wherein the dispensable composition, when cured, is conformable. 
     
     
         48 . The method of  claim 35 , further comprising subjecting the dispensable composition to shear forces during application to the one or more exposed portions, wherein the dispensable composition reduces viscosity when subjected to the shear forces. 
     
     
         49 . The method of  claim 35 , wherein the dispensable composition has a curing time at 23° C. in the range from 0.5 to 5 min. 
     
     
         50 . The method of  claim 35 , wherein the dispensable composition has a curing time at 32° C. in the range from 0.5 to 7 min. 
     
     
         51 . The method of  claim 35 , further comprising dispensing the dispensable composition directly at the exposed portion through an exposed face of the one or more transmission layers.