US2016115458A1PendingUtilityA1
Tumor therapy with replication competent sindbis viral vectors
Est. expiryFeb 21, 2028(~1.6 yrs left)· nominal 20-yr term from priority
A61P 35/00G01N 33/575A61K 35/768A61K 48/0058C12N 2770/36145C12N 15/86C12N 2770/36171C12N 9/78G01N 2800/52C12N 7/00C12N 2770/36143A61K 51/0491C12N 2770/36132C12Y 207/01021A61K 38/45A61K 38/00C12N 2830/007C12N 9/1211
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Claims
Abstract
Disclosed herein are methods for treating a mammal harboring a solid tumor which expresses higher levels of High Affinity Laminin Receptors (LAMR) than normal cells of the same lineage comprising systematically administering to a mammal in need of such treatment a therapeutically effective amount of a Replication Competent (RC) Sindbis virus vector, wherein said vector encodes a suicide gene.
Claims
exact text as granted — not AI-modified1 - 32 . (canceled)
33 . A Replication competent (RC) mut-4 Sindbis virus vector comprising SEQ. ID NOS.: 2-8.
34 . The RC mut-4 Sindbis virus vector of claim 33 further comprising a suicide gene.
35 . The RC mut-4 Sindbis virus vector of claim 34 wherein said suicide gene is herpes simplex virus thymidine kinase (HSVtk).
36 . The RC mut-4 Sindbis virus vector of claim 34 wherein said suicide gene is cytosine deaminase.
37 . The RC mut-4 Sindbis virus vector of claim 34 wherein said suicide gene is Varicella Zoster virus thymidine kinase.
38 . The RC mut-4 Sindbis virus vector of claim 34 wherein the genome of said vector is in a single component.
39 . (canceled)
40 . A RC mut-4 Sindbis virus vector comprising the proteins encoded by SEQ ID NOS: 2-5.
41 . The RC mut-4 Sindbis virus vector of claim 40 further comprising the proteins encoded by SEQ ID NOS: 6-7.
42 . The RC mut-4 Sindbis virus vector of claim 41 further comprising the proteins encoded by SEQ ID NO: 8.
43 . The RC mut-4 Sindbis virus vector of claim 42 further comprising a suicide gene.
44 . The RC mut-4 Sindbis virus vector of claim 43 wherein said suicide gene is HSVtk.
45 . The RC mut-4 Sindbis virus vector of claim 43 wherein said suicide gene is cytosine deaminase.
46 . The RC mut-4 Sindbis virus vector of claim 43 wherein said suicide gene is Varicella Zoster virus thymidine kinase.
47 . The RC mut-4 Sindbis virus vector of claim 43 wherein the genome of said vector is in a single component.Join the waitlist — get patent alerts
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