Composition and method for the treatment of neurodegeneration

Abstract

A composition and method for the treatment of neurodegeneration and brain-derived neurotrophic factor. The composition and method comprising providing paroxetine, simvastatin, and optionally, an antioxidant.

What is claimed is: 
     
         1 . A composition for the treatment of neurodegeneration comprising:
 paroxetine; and   simvastatin.   
     
     
         2 . The composition of  claim 1  further comprising from about 0.81 mg/kg by weight of said paroxetine and from about 0.081 mg/kg by weight of said simvastatin. 
     
     
         3 . The composition of  claim 1  further comprising an antioxidant. 
     
     
         4 . The composition of  claim 3  further comprising from about 3.24 mg/kg by weight of said antioxidant. 
     
     
         5 . The composition of  claim 3  wherein said antioxidant is an ascorbic acid. 
     
     
         6 . A method for the treatment of neurodegeneration comprising:
 administering a composition comprising paroxetine and simvastatin.   
     
     
         7 . The method of  claim 6  further comprising administering a composition comprising from about 0.81 mg/kg by weight of said paroxetine and from about 0.081 mg/kg by weight of said simvastatin. 
     
     
         8 . The method of  claim 6  further comprising an antioxidant. 
     
     
         9 . The method of  claim 8  further comprising administering a composition comprising from about 3.24 mg/kg by weight of said antioxidant. 
     
     
         10 . The method of  claim 8  wherein said antioxidant is an ascorbic acid. 
     
     
         11 . The method of  claim 6  further comprising administering said composition between at least 20-26 hours after ischemic stroke induction and continuing for at least 31 days.