Sheet for cutaneous application containing vitamin e or an ester thereof

Abstract

Sheet for cutaneous application comprising a support layer made of loosely woven fabric embedded in a layer of silicone elastomer incorporating vitamin E or an ester thereof, wherein the layer of silicone elastomer has a thickness less than or equal to 2.0 mm and the silicone elastomer contains an elasticity modifier consisting of a triglyceride of saturated C 8 -C 18 fatty acids.

1 . A sheet for cutaneous application comprising a support layer made of loosely woven fabric embedded in a layer of silicone elastomer incorporating vitamin E or an ester thereof, wherein said layer of silicone elastomer has a thickness less than or equal to 2.0 mm and said silicone elastomer contains an elasticity modifier consisting of a triglyceride of saturated C 8 -C 18  fatty acids. 
     
     
         2 . The sheet according to  claim 1 , wherein said loosely woven fabric is gauze. 
     
     
         3 . The sheet according to  claim 1 , wherein said silicone elastomer incorporates an ester of vitamin E with a carboxylic acid of formula R—COOH, wherein R is an alkyl radical having 1 to 19 carbon atoms, or an alkenyl or alkynyl radical having 2 to 19 carbon atoms. 
     
     
         4 . The sheet according to  claim 3 , wherein said ester of vitamin E is vitamin E acetate, n-propionate or linoleate. 
     
     
         5 . The sheet according to  claim 4 , wherein said ester of vitamin E is alpha-tocopheryl acetate. 
     
     
         6 . The sheet according to  claim 1 , wherein said vitamin E or ester thereof is contained in said layer of silicone elastomer in an amount of between 2% and 40%. 
     
     
         7 . The sheet according to  claim 1 , wherein said vitamin E or ester thereof is contained in said layer of silicone elastomer in an amount of between 5% and 30%, by weight of the weight of the silicone elastomer. 
     
     
         8 . The sheet according to  claim 1 , wherein said triglyceride of saturated C 8 -C 18  fatty acids is contained in an amount of 1-3% by weight of the weight of the silicone elastomer. 
     
     
         9 . The sheet according to  claim 1 , wherein said triglyceride of saturated C 8 -C 18  fatty acids is selected from the group consisting of Caprylic/Capric Triglyceride, Caprylic/Capric/Stearic Triglyceride and Caprylic/Capric/Myristic/Stearic Triglyceride. 
     
     
         10 . The sheet according to  claim 8 , wherein said triglyceride of saturated C 8 -C 18  fatty acids is Caprylic/Capric Triglyceride. 
     
     
         11 . The sheet according to  claim 1 , wherein said layer of silicone elastomer has a thickness of between 0.2 and 1.5 mm. 
     
     
         12 . The sheet according to  claim 1 , wherein said silicone elastomer is a vinyl-substituted polysiloxane crosslinked with a polyalkyl hydrosiloxane. 
     
     
         13 . The sheet according to  claim 12 , wherein said silicone elastomer is a Bis-Vinyl Dimethicone/Dimethicone Copolymer (INCI nomenclature). 
     
     
         14 . (canceled) 
     
     
         15 . A process for the production of a sheet for cutaneous application comprising a support layer made of loosely woven fabric embedded in a layer of silicone elastomer incorporating vitamin E or an ester thereof, wherein said layer of silicone elastomer has a thickness less than or equal to 2.0 mm, said silicone elastomer contains an elasticity modifier consisting of a triglyceride of saturated C8-C18 fatty acids, and said silicone elastomer is a vinyl-substituted polysiloxane crosslinked with a polyalkyl-hydrosiloxane, which process comprises the steps of:
 a) dispersing at room temperature and while stirring the vitamin E or its ester and the triglyceride of saturated C8-C18 fatty acids in a vinyl-substituted polysiloxane, in an amount equal to 3.8-84.4% and 2.9-21.1% by weight of the vinyl-substituted polysiloxane,   b) adding, again while stirring, a polyalkyl hydrosiloxane in a weight ratio with respect to the vinyl-substituted polysiloxane ranging from 0.9:1.0 to 1.1:1.0, obtaining a homogeneous dispersion;   c) depositing on the support layer made of loosely woven fabric said homogeneous dispersion in a layer with a thickness of 0.2-2.0 mm and leaving it at room temperature for a time sufficient to obtain the formation of the sheet.   
     
     
         16 . The process according to  claim 15 , wherein said vinyl-substituted polysiloxane is Bis-Vinyl Dimethicone and said polyalkylhydrosiloxane is Hydrogen-Dimethicone (INCI nomenclature). 
     
     
         17 . The process according to  claim 15 , wherein in said step a) vitamin E acetate is dispersed in said vinyl-substituted polysiloxane in an amount of between 7.5-45% by weight of the weight of the vinyl-substituted polysiloxane. 
     
     
         18 . The process according to  claim 15 , wherein said support layer made of loosely woven fabric is a cotton gauze. 
     
     
         19 - 22 . (canceled) 
     
     
         23 . The sheet according to  claim 2 , wherein said gauze is a cotton gauze. 
     
     
         24 . A method for preventing the formation of keloids and abnormal wound healing processes and for the treatment of already formed keloids in a skin area of a subject, comprising the application of a the sheet according to  claim 1  to said skin area. 
     
     
         25 . A method for treating sunburn in a skin area of a subject, comprising the application of the sheet according to  claim 1  to said skin area. 
     
     
         26 . A method for relaxing and moisturizing a skin area of a subject, comprising the application of the sheet according to  claim 1  to said skin area.