US2016083437A1PendingUtilityA1

Composition comprising recombinant fusion protein of pathogenic antigen protein and flagellin of vibrio vulnificus for preventing, alleviating, or treating aging

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Assignee: UNIV NAT CHONNAM IND FOUNDPriority: Nov 30, 2012Filed: Mar 27, 2013Published: Mar 24, 2016
Est. expiryNov 30, 2032(~6.3 yrs left)· nominal 20-yr term from priority
Inventors:Kyung A. ChoJae Sung LimJoon Haeng Rhee
A61P 19/00A61P 1/00A61K 2039/58C07K 14/28C07K 14/3156A61K 39/107A61K 39/092A61K 38/164C07K 2319/00A61K 38/16A61K 38/17
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Claims

Abstract

The present invention relates to a composition for preventing, improving, or treating aging, wherein the composition comprises a recombinant protein of flagellin, which is the constituent of Vibrio vulnificus flagella, fused with a pathogenic protein antigen, as an active component. According to the present invention, the recombinant protein of the present invention can improve external and internal aging-related malfunctions and enhance immunity. Also, the composition of the present invention can easily perform immunization through mucosal administration.

Claims

exact text as granted — not AI-modified
1 . A composition for preventing, improving, or treating aging, the composition comprising a recombinant protein of flagellin, which is the constituent of  Vibrio vulnificus  flagella, fused with a pathogenic protein antigen, as an active ingredient. 
     
     
         2 . The composition according to  claim 1 , wherein the flagellin is FlaB, which is flagellin of  Vibrio vulnificus.    
     
     
         3 . The composition according to  claim 1 , wherein the pathogenic protein antigen is surface protein A (PspA) of  Streptococcus pneumonia.    
     
     
         4 . The composition according to  claim 1 , wherein the recombinant protein is FlaB-PspA protein having an amino acid sequence of SEQ ID NO: 1. 
     
     
         5 . The composition according to  claim 1 , wherein the recombinant protein enhances immunity. 
     
     
         6 . A composition for preventing, improving, and treating metabolic disease, the composition comprising the recombinant protein of  claim 1 , as an active ingredient. 
     
     
         7 . A composition for preventing, improving, and treating hair-related disease, the composition comprising the recombinant protein of  claim 1 , as an active ingredient. 
     
     
         8 . A composition for preventing, improving, and treating eye disease, the composition comprising the recombinant protein of  claim 1 , as an active ingredient. 
     
     
         9 . A composition for preventing, improving, and treating bowel disease, the composition comprising the recombinant protein of  claim 1 , as an active ingredient. 
     
     
         10 . A composition for preventing, improving, and treating bone disease, the composition comprising the recombinant protein of  claim 1 , as an active ingredient. 
     
     
         11 . A method for preventing, improving, or treating aging, the method comprising administering to a subject the composition of  claim 1 .

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