Agent for the anti-adhesion of skin pathogenic flora

Abstract

Bacterial agents for preparing compositions which are for cosmetic, pharmaceutical or veterinary use and which are intended to stabilize and/or regulate the cutaneous ecosystem of mammals. These bacterial agents being an extract of a bacterium, or a bacterium, selected for their adhesion to skin cells and anti-adhesive to pathogens of the cutaneous system. The invention also relates to compositions containing such agents.

The invention is claimed as follows: 
     
         1 . A method for treatment or prevention of a skin disorder selected from the group consisting of superinfected atopic dermatitis, impetigo-based eczema, ulcers, infectious complications from a wound, burns, superinfected inflammatory acne, impetigo, superficial folliculitis, seborrhoeic dermatitises, pityriasis versicolor, dermatophytoses, candidiases, skin disorders caused by antibiotic therapy, skin disorders caused by antimycotic agents, skin disorders caused by hormonal dysregulation, and dandruff, the method comprising administering by a topical route to a subject in need thereof a composition comprising a bacterial agent that is at least one of  Lactobacillus johnsonii  CNCM 1-1225 or  Micrococcus varians  NCC 1482. 
     
     
         2 . The method of  claim 1 , wherein the subject has the skin disorder. 
     
     
         3 . The method of  claim 1 , wherein the composition is a liquid. 
     
     
         4 . The method of  claim 1 , wherein the composition is selected from the group consisting of a salve, a cream, a milk, a gel, a body lotion, a soap and a shampoo. 
     
     
         5 . The method of  claim 1 , wherein the composition is a powder. 
     
     
         6 . The method of  claim 1 , wherein the composition comprises at least 10×10 6  cfu of the bacterial agent/g of the composition. 
     
     
         7 . The method of  claim 1 , wherein the composition comprises 0.05 to 3 wt. % of the bacterial agent. 
     
     
         8 . The method of  claim 1 , wherein the composition is administered to provide an amount of the bacterial agent that inhibits adhesion of at least one pathogen selected from the group consisting of  Staphylococcus aureus, Streptococcus pyogenes  and  Propionibacterium acnes.    
     
     
         9 . The method of  claim 1 , wherein the bacterial agent is deactivated.