Invisible Antimicrobial Glove and Hand Antiseptic

Abstract

An alcohol based hand surgical scrub, which includes cationic anti-microbial agent preservatives, cationic polymer film-forming agents and a skin emollient, and provides a long term residual, anti-microbial “invisible glove” on the skin. The composition provides an immediate reduction in bacterial microbes. The polymer system creates an invisible film on the skin following solvent evaporation. This invisible film provides a lasting anti-microbial barrier on the skin which acts to prevent microbial growth.

What is claimed is: 
     
         1 . A surgical scrub composition comprising:
 (a) from 60% by weight (% wt) to 95% wt of the entire composition of one or more alcohols;   (b) from 0.05% wt to 5% wt of the entire composition of a combination of one of chlorhexidine digluconate, benzethonium chloride, or benzalkonium chloride and one or more additional cationic anti-microbial agents;   (c) from 0.1% wt to 5% wt of the entire composition of a skin emollient system including at least 1-docosanol and PEG-10 behenyl ether;   (d) from 0.05% wt to 5% wt of the entire composition of a 25% active solution of behenyl trimonium methosulfate in cetearyl alcohol; and   (e) a self-emulsifier, comprising cetearyl alcohol, castor oil, and stearalkonium chloride.   
     
     
         2 . The surgical scrub composition of  claim 1 , further comprising a silicone. 
     
     
         3 . The surgical scrub composition of  claim 2 , wherein the silicone includes one or more of the group of dimethicone copolyol, cyclomethicone and dimethicone. 
     
     
         4 . The surgical scrub composition of  claim 1 , further comprising one or more of the group of methylparaben and propylparaben. 
     
     
         5 . The surgical scrub composition of  claim 1 , wherein the additional anti-microbial agent is one or more of the group including chlorhexidine digluconate, chloroxylenol, parachloro-meta-xylenol, chlorhexidine diacetate, benzethonium chloride, benzalkonium chloride, hexetidine, diazolidinyl urea, methyl chloro isothiazoline, methyl isothiazoline, triclosan, hexachlorophenes, octenidine, and quaternary compounds. 
     
     
         6 . The surgical composition of  claim 1 , wherein the polymer system additionally includes one or more of the group including a stearalkonium chloride containing compound, cellulose, polyvinylpyrolidone and waxes. 
     
     
         7 . A method of disinfecting the skin comprising:
 (a) applying a surgical scrub composition to the skin prior to a surgical procedure, the surgical scrub composition including:
 i. from 60% by weight (% wt) to 95% wt of the entire composition of one or more alcohols; 
 ii. from 0.05% wt to 5% wt of the entire composition of a combination of one of chlorhexidine digluconate, benzethonium chloride, or benzalkonium chloride and one or more additional cationic anti-microbial agents; 
 iii. from 0.1% wt to 5% wt of the entire composition of a skin emollient system including at least 1-docosanol and PEG-10 behenyl ether; 
 iv. from 0.05% wt to 5% wt of the entire composition of a 25% active solution of behenyl trimonium methosulfate in cetearyl alcohol; and 
 v. from greater than 0% wt to 5% wt of the entire composition of a self-emulsifier; and 
   (b) rubbing the skin with the composition until the alcohol has evaporated.   
     
     
         8 . A method of using a surgical scrub composition for hand antisepsis comprising:
 (a) applying a cleansing liquid to skin;   (b) scrubbing the skin with an anti-microbial scrub solution;   (c) rinsing the anti-microbial scrub solution from the skin; and   (d) applying to the skin the surgical scrub composition according to  claim 1 .   
     
     
         9 . The method of  claim 8 , wherein the surgical scrub composition includes:
 the alcohol in an amount from about 60% wt to 95% wt of the total composition;   the cationic anti-microbial agent in an amount from about 0.1% wt to about 5% wt of the total composition;   the skin emollient system in an amount from about 0.1% wt to about 5% wt of the total composition; and   the film-forming cationic polymer system in amount from about 0.1% wt to about 5% wt of the total composition.   
     
     
         10 . The method of  claim 9 , wherein the surgical scrub composition includes a silicone in an amount from about 0.1% wt to about 5% wt of the total composition. 
     
     
         11 . The method of  claim 8 , wherein the film-forming polymer system additionally includes one or more of the group including a stearalkonium chloride containing compound, cellulose, polyvinylpyrolidone and waxes. 
     
     
         12 . The method of  claim 8 , wherein the effective amount is 20cc. 
     
     
         13 . A surgical scrub composition comprising:
 (a) one or more alcohols in an amount from about 60% by weight (% wt) to 95% wt of the total composition;   (b) one or more film-forming cationic polymers in an amount from about 0.1% wt to about 5% wt of the total composition, wherein the one or more film-forming cationic polymers include a behenyl trimonium methosulfate containing compound;   (c) a combination of chlorhexidine digluconate, benzethonium chloride, and benzalkonium chloride in an amount from about 0.1% wt to about 5% wt of the total composition;   (d) at least two skin emollients in a total amount from about 0.1% wt to about 5% wt of the total composition, wherein the at least two skin emollients include 1-docosanol and PEG-10 behenyl ether; and   (e) a self-emulsifier.   
     
     
         14 . The surgical scrub composition of  claim 13 , further comprising from about 0.01% wt to 5% wt of a silicone. 
     
     
         15 . A surgical scrub composition comprising:
 (a) a preservative;   (b) chlorhexidine digluconate and one or more additional cationic anti-microbial agents;   (c) a film-forming system including a behenyl trimonium methosulfate containing compound, a self-emulsifier and further including at least one of the group containing glycerin, methylparaben or propylparaben;   (d) from 60% by weight (% wt) to 95% wt of alcohol;   (e) water; and   (f) a skin emollient system including at least 1-docosanol and PEG-10 behenyl ether.   
     
     
         16 . A surgical scrub composition comprising:
 (a) from 60% by weight (% wt) to 95% wt of one or more alcohols selected from the group of ethyl alcohol, isopropyl alcohol, ethanol and n-propanol;   (b) from 0.05% wt to 0.27% wt of chlorhexidine digluconate and one or more additional cationic anti-microbial agents selected from the group consisting of chloroxylenol, para-chloro-meta-xylenol, chlorhexidine diacetate, benzethonium chloride, benzalkonium chloride, hexetidine, diazolidinyl urea, methyl chloro isothiazoline, methyl isothiazoline, triclosan, hexachlorophenes, octenidine and quaternary compounds;   (c) a skin emollient system including at least 1-docosanol and PEG-10 behenyl ether;   (d) a film-forming cationic polymer system including a behenyl trimonium methosulfate containing compound and one or more selected from the group of cellulose, polyvinylpyrolidone, waxes, and stearalkonium chloride containing compounds; and   (e) a self-emulsifier.   
     
     
         17 . The surgical scrub composition of  claim 16 , further comprising a silicone. 
     
     
         18 . The surgical scrub composition of  claim 16 , further comprising one or more of methylparaben or propylparaben. 
     
     
         19 . The surgical scrub composition of  claim 1 , wherein the composition comprises 0.09% wt chlorhexidine digluconate, 0.09% wt benzethonium chloride, and 0.09% wt benzalkonium chloride.