Antimicrobial Compounds

Abstract

This disclosure relates to compositions including certain compounds identified by a quantitative, high throughput assay to be effective in inhibiting the ability of a bacterium to kill a host organism, as well as methods for using these compounds for treating bacterial infections.

What is claimed is: 
     
         1 . A pharmaceutical composition, comprising a pharmaceutically acceptable carrier and a compound of formula (VII): 
       
         
           
           
               
               
           
         
         wherein 
         each of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , independently, is H, C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl, C 3 -C 20  cycloalkyl, C 3 -C 20  cycloalkenyl, C 1 -C 20  heterocycloalkyl, C 1 -C 20  heterocycloalkenyl, aryl, heteroaryl, halo, OR a , SR a , COOR a , OC(O)R a , C(O)R a , C(O)NR a R b , or NR a R b , in which each of R a  and R b , independently, is H, C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl, C 3 -C 20  cycloalkyl, C 3 -C 20  cycloalkenyl, C 1 -C 20  heterocycloalkyl, C 1 -C 20  heterocycloalkenyl, aryl, or heteroaryl; 
         or a salt thereof. 
       
     
     
         2 . The composition of  claim 1 , wherein R 6  is OR a . 
     
     
         3 . The composition of  claim 2 , wherein R a  is H. 
     
     
         4 . The composition of  claim 3 , wherein each of R 3  and R 5  is halo. 
     
     
         5 . The composition of  claim 4 , wherein each of R 3  and R 5  is Cl. 
     
     
         6 . The composition of  claim 5 , wherein the compound is 
       
         
           
           
               
               
           
         
       
     
     
         7 . The composition of  claim 3 , wherein each of R 3  and R 5  is C 1 -C 10  alkyl. 
     
     
         8 . The composition of  claim 7 , wherein each of R 3  and R 5  is CH 3 . 
     
     
         9 . The composition of  claim 8 , wherein the compound is 
       
         
           
           
               
               
           
         
       
     
     
         10 . A method of treating a bacterial infection in a subject in need thereof, comprising administering to the subject the pharmaceutical composition of  claim 1  in an amount effective to treat the infection. 
     
     
         11 . The method of  claim 10 , wherein the bacterial infection is community-acquired pneumonia, upper and lower respiratory tract infection, skin and soft tissue infection, bone and joint infection, hospital-acquired infection, acute bacterial otitis media, bacterial pneumonia, complicated infection, noncomplicated infection, pyelonephritis, intra-abdominal infection, deep-seated abscess, bacterial sepsis, central nervous system infection, bacteremia, wound infection, peritonitis, meningitis, infections after burn, urogenital tract infection, gastro-intestinal tract infection, pelvic inflammatory disease, endocarditis, or intravascular infection. 
     
     
         12 . The method of  claim 11 , wherein the bacterial infection is gastro-intestinal tract infection.