Eurycoma longifolia extract and its use in enhancing and/or stimulating immune system

Abstract

The present invention discloses the use of a composition comprising an effective amount of an extract of Eurycoma longifolia for the production of a preparation to stimulate and/or enhance the immune system. In a preferred embodiment, the extract comprises active ingredients, which include eurycomanone, protein, polysaccharide and glycosaponin in appropriate amounts. In another preferred embodiment, the extract has an activity selected from the group consisting of: increasing the number of T-cells; improving Scoring of Immunological Vigor (SIV), a comprehensive index of overall immune function; lowering the immunological age, a comprehensible form of immune function based on T-cell number and proliferative activity; reducing fatigue; and alleviating or reducing stress. Also disclosed is a method of for treating an individual to achieve an outcome selected from the group consisting of increasing the number of T-cells, improving SIV (i.e. a comprehensive index of overall immune function), lowering the immunological age (i.e. a comprehensible form of immune function), reducing fatigue and alleviating or reducing stress comprising administering to the individual an effective amount of an extract of Eurycoma longifolia.

1 . Use of a composition comprising an effective amount of an extract of  Eurycoma longifolia  for the manufacture of a preparation to stimulate and/or enhance the immune system. 
     
     
         2 . The use according to claim, wherein the extract of  Eurycoma longifolia  is an aqueous extract or a solvent extract. 
     
     
         3 . The use according to  claim 1 , wherein the extract comprises active ingredients, which include eurycomanone, protein, polysaccharide and glycosaponin in appropriate amounts. 
     
     
         4 . The use according to  claim 1 , wherein the extract has an activity selected from the group consisting of:
 increasing the number of T-cells;   improving Scoring of Immunological Vigor (SIV), a comprehensive index of overall immune function;   lowering the immunological age, a comprehensible form of immune function based on T-cell number and proliferative activity;   reducing fatigue; and   alleviating or reducing stress.   
     
     
         5 . The use according to  claim 4 , wherein the Scoring of Immunological Vigor (SIV) comprises the optimal functioning of T-cells, CD4+/CD8+ ratio, Naive T-cell, Naive/Memory T-cell ratio, B cells, NK cells and T proliferative activity. 
     
     
         6 . The use according to  claim 1 , wherein the composition further includes a pharmaceutically or nutraceutically acceptable carrier. 
     
     
         7 . A composition comprising an effective amount of an extract of  Eurycoma longifolia  and a pharmaceutically or nutraceutically acceptable carrier to stimulate and/or enhance the immune system. 
     
     
         8 . A composition according to  claim 7 , wherein the extract of  Eurycoma longifolia  is an aqueous extract or a solvent extract. 
     
     
         9 . A composition according to  claim 7 , wherein the extract comprises active ingredients, which include eurycomanone, protein, polysaccharide and glycosaponin in appropriate amounts. 
     
     
         10 . A composition according to  claim 7 , having an activity selected from the group consisting of:
 increasing the number of T-cells;   improving Scoring of Immunological Vigor (SIV), a comprehensive index of overall immune function;   lowering the immunological age, a comprehensible form of immune function based on T-cell number and proliferative activity;   reducing fatigue; and   alleviating or reducing stress.   
     
     
         11 . A method for treating an individual to achieve an outcome selected from the group consisting of increasing the number of T-cells, improving Scoring of Immunological Vigor, SIV (i.e. a comprehensive index of overall immune function), lowering the immunological age (i.e. a comprehensible form of immune function), reducing fatigue and alleviating or reducing stress, comprising administering to the individual an effective amount of an extract of  Eurycoma longifolia.    
     
     
         12 . A method according to  claim 11 , wherein the extract of  Eurycoma longifolia  is an aqueous extract or a solvent extract. 
     
     
         13 . A method according to  claim 11 , wherein the extract comprises active ingredients, which include eurycomanone, protein, polysaccharide and glycosaponin in appropriate amounts. 
     
     
         14 . A method according to  claim 11 , wherein the amount effective comprising from 10 mg to 2000 mg. 
     
     
         15 . A method according to  claim 14 , wherein the amount effective comprising from 200 mg to 400 mg. 
     
     
         16 . A method according to  claim 11 , wherein the extract of  Eurycoma longifolia  enhances and/or stimulates the immune function and has an anti-aging effect, which leads to protecting the body of the individual from infectious diseases. 
     
     
         17 . A method according to  claim 11 , wherein the extract further includes a pharmaceutically or nutraceutically acceptable carrier.