US2016067215A1PendingUtilityA1

Method and Composition for Treating Heart Failure

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Individually held — no corporate assignee on recordPriority: Oct 5, 2007Filed: Nov 17, 2015Published: Mar 10, 2016
Est. expiryOct 5, 2027(~1.2 yrs left)· nominal 20-yr term from priority
Inventors:Wesley W. BrooksOscar H.L. Bing
A61K 31/40A61K 31/401A61K 45/06A61K 31/216A61P 9/04A61P 9/00A61K 31/192
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Claims

Abstract

A method and composition for treating, preventing or ameliorating heart failure, cardiac hypertrophy, and/or myocardial dysfunction includes administering a therapeutically effective amount of a HDAC inhibitor, such as phenylbutyrate, in combination with an ACE inhibitor, such as captopril.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method of preventing cardiac gene expression changes associated with heart failure, comprising:
 administering to a subject in need thereof a therapeutically effective amount of a composition including a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or ester thereof, and an angiotensin converting enzyme (ACE) inhibitor, angiotensin receptor blocker, beta adrenergic receptor blocker, or a pharmaceutically acceptable salt or ester thereof.   
     
     
         2 . A method of preventing myocardial dysfunction, comprising:
 administering to a subject in need thereof a therapeutically effective amount of a composition including a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or ester thereof, and an angiotensin converting enzyme (ACE) inhibitor, angiotensin receptor blocker, beta adrenergic receptor blocker, or a pharmaceutically acceptable salt or ester thereof.

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