Novel Epitope for Switching to TH2 Cell and Use Thereof

Abstract

The present invention relates to a novel epitope to convert T cell to type 2 helper T (T H 2) cell. Specifically, the present invention relates to an epitope constituting the 20 th to 30 th amino acids (SEQ ID No.2) of extracellular domain (ECD) of activation-inducible tumor necrosis factor receptor (AITR), an antibody recognizing the epitope, a polynucleotide encoding the epitope, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide encoding the epitope or antibody, a transformant introduced with the vector, a composition comprising the antibody for converting T cell to T H 2 cell and a method of conversion, a pharmaceutical composition comprising the antibody for preventing or treating autoimmune disease, and a method for treating autoimmune disease using the antibody.

1 . A polypeptide which is an epitope of activation-inducible tumor necrosis factor receptor (AITR), defined as an amino acid sequence represented by SEQ ID No.2, for converting T cell to type 2 helper T (T H 2) cell. 
     
     
         2 . A polynucleotide encoding the polypeptide of  claim 1 .