Polycarbonate microfluidic articles

Abstract

Microfluidic devices, and methods for their use are described. The microfluidic devices include articles formed from a thermoplastic composition comprising a poly(aliphatic ester)-polycarbonate comprising soft block ester units, derived from monomers comprising an alpha, omega C 6-20 aliphatic dicarboxylic acid or derivative thereof, a dihydroxyaromatic compound, and a carbonate source.

1 . A microfluidic device, comprising
 a fluid sample in a channel or microwell that includes a wall having a fabricated thickness of less than or equal to 1 mm formed from a thermoplastic composition comprising:   a poly(aliphatic ester)-polycarbonate comprising soft block ester units, derived from monomers comprising:   an alpha, omega C 6-20  aliphatic dicarboxylic acid or derivative thereof,   a dihydroxyaromatic compound, and   a carbonate source.   
     
     
         2 . The microfluidic device of  claim 1 , wherein the fabricated dimension is 0.005 to 1 mm. 
     
     
         3 . The microfluidic device of  claim 1 , wherein the fabricated dimension is 0.01 to 0.5 mm. 
     
     
         4 . The microfluidic device of  claim 1 , wherein the fabricated dimension is 0.05 to 0.2 mm. 
     
     
         5 . The microfluidic device of  claim 1 , wherein the thermoplastic composition has a melt flow rate of 66 to 150 g/10 min at 300° C. under a load of 1.2 kilograms according to ASTM D1238-10. 
     
     
         6 . The microfluidic device of  claim 1 , wherein the thermoplastic composition has an HDT is 80 to 140° C. at 0.45 mega Pascal (MPa) with an unannealed 3.2 mm plaque according to ASTM D648-07. 
     
     
         7 . The microfluidic device of  claim 6 , wherein the thermoplastic composition has a Notched Izod Impact (NII) ductility of 30 to 100%, with a ⅛-inch thick bar (3.18 mm) at 23° C. according to ASTM D256-10. 
     
     
         8 . The microfluidic device of  claim 1 , wherein the thermoplastic composition has an HDT is 80 to 140° C. at 1.82 mega Pascal (MPa) with an unannealed 3.2 mm plaque according to ASTM D648-07. 
     
     
         9 . The microfluidic device of  claim 8 , wherein the thermoplastic composition has a Notched Izod Impact (NII) ductility of 30 to 100%, with a ⅛-inch thick bar (3.18 mm) at 23° C. according to ASTM D256-10. 
     
     
         10 . The microfluidic device method of  claim 1 , wherein the thermoplastic composition has a Notched Izod Impact (NII) ductility of 30 to 100%, with ⅛-inch thick bars (3.18 mm) at 23° C. according to ASTM D256-10. 
     
     
         11 . The microfluidic device of  claim 1 , wherein the article has a Notched Izod Impact (NII) of 400 to 700 Joules per meter (J/m) with ⅛-inch thick bars (3.18 mm) at 23° C. according to ASTM D256-10. 
     
     
         12 . The microfluidic device of  claim 1 , wherein the fluid is at a process temperature of at least 90° C. 
     
     
         13 . The microfluidic device of  claim 12 , wherein the process temperature is less than or equal to 120° C. 
     
     
         14 . The microfluidic device of  claim 12 , wherein the process temperature is less than or equal to 110° C. 
     
     
         15 . The microfluidic device of  claim 12 , wherein the process temperature is at least 95° C. 
     
     
         16 . The microfluidic device of  claim 12 , wherein the process temperature is from 95° C. to 105° C. 
     
     
         17 . The microfluidic device of  claim 1 , wherein the wall having a fabricated thickness of less than or equal to 1 mm is a wall having a molded thickness of less than or equal to 1 mm. 
     
     
         18 . The microfluidic device of  claim 17 , wherein the molded thickness is 0.005 to 1 mm. 
     
     
         19 . The microfluidic device of  claim 17 , wherein the molded thickness is 0.01 to 0.5 mm. 
     
     
         20 . The microfluidic device of  claim 17 , wherein the molded thickness is 0.05 to 0.2 mm.