US2016041145A1PendingUtilityA1

Detection And Quantification Of Acetylamantadine In Urine Samples

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Assignee: BIOMARCK TECHNOLOGIES INCPriority: Mar 14, 2013Filed: Mar 14, 2014Published: Feb 11, 2016
Est. expiryMar 14, 2033(~6.6 yrs left)· nominal 20-yr term from priority
Inventors:Reuven GordonBrian K. ChengRashid BuxBram RamjiawanAftab J. AhmedFraser Hof
G01N 33/5758G01N 33/575G01N 33/493G01N 21/658G01N 1/4055A61B 5/0075C12Q 1/48G01N 15/0205G01N 15/1434G01N 21/65G01N 27/44721G01N 27/74
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Claims

Abstract

A method for quantifying acetylamantadine in a urine sample comprises eluting acetylamantadine from the urine sample using solid phase extraction and quantifying the acetylamantadine eluted from the urine sample using Raman spectroscopy.

Claims

exact text as granted — not AI-modified
1 . A method for quantifying acetylamantadine in a urine sample, the method comprising:
 eluting acetylamantadine from the urine sample using solid phase extraction; and   quantifying the acetylamantadine eluted from the urine sample using substrate based, surface enhanced Raman spectroscopy.   
     
     
         2 . The method as claimed in  claim 1  wherein the solid phase extraction includes eluting acetylamantadine with methanol. 
     
     
         3 . The method as claimed in  claim 1  wherein quantifying the acetylamantadine eluted from the urine sample using Raman spectroscopy includes quantifying the acetylamantadine based on a 1600 cm−1 band. 
     
     
         4 . The method as claimed in  claim 1  wherein quantifying the acetylamantadine eluted from the urine sample using Raman spectroscopy includes quantifying the acetylamantadine with a sensitivity of 1 mg/mL. 
     
     
         5 . Use of the method as claimed in  claim 1  to screen a patient for a pathological condition based on the quantification of acetylamantadine in the urine sample. 
     
     
         6 . Use of the method as claimed in  claim 1  to screen a patient for cancer based on the quantification of acetylamantadine in the urine sample.

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