Method and kit for genetic analysis

Abstract

Methods and kits for assessing severity index for alcohol abuse, drug abuse, and other reward deficiency syndromes. It has been discovered that a multifaceted non-specific RDS behaviors should be considered as the true “reward” phenotype (endophenotype) instead of a single subset RDS behavior such as alcoholism. In an embodiment of the present invention, it has been discovered that there are at least eleven risk alleles associated with ten candidate genes. The methods and kits of the present invention satisfy the need to classify patients at genetic risk for drug/alcohol seeking behavior prior to or upon entry to residential and or non-residential chemical dependency and pain programs.

1 - 11 . (canceled) 
     
     
         12 . A method comprising a genotypic analysis of a panel of genes to identify a plurality of alleles comprising:
 (a) allele G of gene DRD1;   (b) allele A1 of gene DRD2;   (c) allele C of gene DRD3;   (d) allele C of gene DRD4;   (e) allele 9R of gene DAT1;   (f) allele 7-11R of gene DRD4;   (g) allele S or L of gene HTTLPR;   (h) allele 4R of gene MAOA;   (i) allele G of gene COMT;   (j) allele G of gene OPRM1; and   (k) allele 181 of gene GABRB3.   
     
     
         13 . A kit for analyzing a panel of genes comprising primers for sequencing (5′ to 3′) consisting of:
 (l) allele G of gene DRD1; 
 (m) allele A1 of gene DRD2; 
 (n) allele C of gene DRD3; 
 (o) allele C of gene DRD4; 
 (p) allele 9R of gene DAT1; 
 (q) allele 7-11R of gene DRD4; 
 (r) allele S or L of gene HTTLPR; 
 (s) allele 4R of gene MAOA; 
 (t) allele G of gene COMT; 
 (u) allele G of gene OPRM1; and 
 (v) allele 181 of gene GABRB3. 
 
     
     
         14 - 19 . (canceled)