Neural response system

Abstract

A neural response system, including a plurality of filters for each receiving and filtering a plurality of tilt response signals obtained from a person; a segmenter for segmenting the filtered response signals into time segments; and a neural event extractor for performing a neural event extraction process on each of the time segments to obtain and generate biomarker data representing a plurality of biomarkers for each segment.

1 . A neural response system, including:
 different types of filters each configured to receive and filter a plurality neural response signals obtained from a person under different conditions;   a segmenter for segmenting each of the filtered response signals into time segments; and   a neural event extractor for performing a neural event extraction process on each of the time segments to obtain and generate biomarker data representing a plurality of biomarkers for each segment, the biomarker data for determining whether said person has a condition.   
     
     
         2 . A neural response system as claimed in  claim 1 , wherein the neural response signals are obtained from at least one electrode connected to at least one ear of the person subjected to a plurality of tilt sequences in a tilt chair. 
     
     
         3 . A neural response system as claimed in  claim 1 , wherein the filters include at least one of a notch filter to substantially pass all frequencies, a first high pass filter and a second high pass filter. 
     
     
         4 . A neural response system as claimed in  claim 3 , wherein the cut-off frequency for the first filter is about 5 Hz and the cut-off frequency for the second filter is about 120 Hz. 
     
     
         5 . A neural response systems as claimed in  claim 1 , wherein the neural event extractor generates curve data representing a Sp/Ap field potential curve for each segment. 
     
     
         6 . A neural response system as claimed in  claim 5 , wherein the biomarker data is determined using the curve data and the biomarkers represent relationships and constants associated with the field potential curve. 
     
     
         7 . A neural response system as claimed in  claim 5 , wherein the biomarker data is determined using the curve data and the biomarkers represent spike rates, and time and voltage measurements of the field potential curve. 
     
     
         8 . A neural response system as claimed in  claim 5 , wherein the biomarker data is determined using the curve data and the biomarkers represent ratios, angles and areas associated with the field potential curve. 
     
     
         9 . A neural response system as claimed in  claim 1 , including a diagnostic tool for comparing the biomarker data of each segment with fingerprint data for said condition, and recording deviation measures between said the fingerprint data and the biomarker data. 
     
     
         10 . A neural response system as claimed in  claim 9 , wherein recording the deviations includes summing the deviations, and the diagnostic tool compares sums with the fingerprint data for the biomarkers. 
     
     
         11 . A neural response system as claimed in  claim 1 , wherein the biomarkers represent a comparison between a background phase and an acceleration or deceleration phase of the response signals. 
     
     
         12 . A neural response system as claimed in  claim 1 , including a tilt chair for subjecting the person to a plurality of tilt sequences, and at least one electrode connected to at least one ear of the person and an amplifier circuit to record the tilt response signals produced in response to each neural sequence. 
     
     
         13 . A neural response system as claimed in  claim 12 , wherein the tilt sequences include at least one of up/down, front/back, ipsilateral, contralateral, and rotation. 
     
     
         14 . A neural response system as claimed in  claim 13 , wherein the up/down and rotation sequences includes sequences with the patient upright and sequences with the person prone. 
     
     
         15 . A neural response system as claimed in  claim 14 , wherein electrodes are connected to each ear of the person to record the neural response signals produced in response to each tilt sequence for the left ear and the right ear. 
     
     
         16 . A neural response system as claimed in  claim 1 , wherein the biomarker data indicates whether the person has at least one condition being a neurological disorder and/or neurodegenerative disease. 
     
     
         17 . A neural response system as claimed in  claim 16 , wherein the condition includes one of benign positional paroxysmal vertigo (BPPV), Meniere's disease, Parkinson's disease, Schizophrenia, depression, BiPolar Affective Disorder, Alzheimers, Dementia, Attention Deficit and Hyperactivity Disorder, Multiple Sclerosis, Huntington's Chorea and Creutzfeldt Jakob disease. 
     
     
         18 . A neural response system as claimed in  claim 1 , wherein the biomarker data indicates an effect arising from administration of a pharmaceutical and/or physical therapy. 
     
     
         19 . A neural response system as claimed in  claim 1 , wherein the biomarker data is used to differentiate a diagnosis between conditions having similar symptoms. 
     
     
         20 . A neural response system as claimed in  claim 19 , wherein the conditions are benign positional paroxysmal vertigo (BPPV) and Meniere's disease. 
     
     
         21 . A neural response system as claimed in  claim 19 , wherein the conditions are clinical depression and a depressive phase of a BiPolar Affective Disorder. 
     
     
         22 . A neural response process, including:
 receiving and filtering, using different types of filters, a plurality of neural response signals obtained from a person under different conditions and filtering the neural response signals with each of said filters;   segmenting the filtered response signals into time segments; and   processing each of the time segments to obtain and generate biomarker data representing a plurality of biomarkers for each segment, the biomarker for determining whether said person has a condition.   
     
     
         23 . A neural response process as claimed in  claim 22 , wherein the neural response signals are obtained from at least one electrode connected to at least one ear of the person subjected to a plurality of tilt sequences in a tilt chair. 
     
     
         24 . A neural response process as claimed in  claim 22 , wherein the filters include at least one of a notch filter to substantially pass all frequencies, a first high pass filter and a second high pass filter. 
     
     
         25 . A neural response process as claimed in  claim 24 , wherein the cut-off frequency for the first filter is about 5 Hz and the cut-off frequency for the second filter is about 120 Hz. 
     
     
         26 . A neural response process as claimed in  claim 22 , wherein said processing generates curve data representing a Sp/Ap field potential curve for each segment. 
     
     
         27 . A neural response process as claimed in  claim 26 , wherein the biomarker data is determined using the curve data and the biomarkers represent relationships and constants associated with the field potential curve. 
     
     
         28 . A neural response process as claimed in  claim 26 , wherein the biomarker data is determined using the curve data and the biomarkers represent spike rates, and time and voltage measurements of the field potential curve. 
     
     
         29 . A neural response process as claimed in  claim 26 , wherein the biomarker data is determined using the curve data and the biomarkers represent ratios, angles and areas associated with the field potential curve. 
     
     
         30 . A neural response process as claimed in  claim 22 , including comparing the biomarker data of each segment with fingerprint data for the condition, and recording deviation measures between said the fingerprint data and the biomarker data. 
     
     
         31 . A neural response process as claimed in  claim 30 , wherein recording the deviations includes summing the deviations, and the sums are compared with the fingerprint data for the biomarkers to determine whether said person has said condition. 
     
     
         32 . A neural response process as claimed in  claim 22 , wherein the biomarkers represent a comparison between a background phase and an acceleration or deceleration phase of the response signals. 
     
     
         33 . A neural response process as claimed in  claim 22 , wherein the tilt sequences include at least one of up/down, front/back, ipsilateral, contralateral, and rotation. 
     
     
         34 . A neural response process as claimed in  claim 33 , wherein the up/down and rotation sequences includes sequences with the person upright and sequences with the person prone. 
     
     
         35 . A neural response process as claimed in  claim 34 , including connecting electrodes to each ear of the person to record the neural response signals produced in response to each tilt sequence for the left ear and the right ear. 
     
     
         36 . A neural response process as claimed in  claim 22 , wherein the biomarker data indicates whether the person has at least one condition being a neurological disorder and/or neurodegenerative disease. 
     
     
         37 . A neural response process as claimed in  claim 36 , wherein the condition includes one of benign positional paroxysmal vertigo (BPPV), Meniere's disease, Parkinson's disease, Schizophrenia, depression, BiPolar Affective Disorder, Alzheimers, Dementia, Attention Deficit and Hyperactivity Disorder, Multiple Sclerosis, Huntingdon's Chorea and Creutzfeldt Jakob disease. 
     
     
         38 . A neural response process as claimed in  claim 22 , wherein the biomarker data indicates an effect arising from administration of a pharmaceutical and/or physical therapy. 
     
     
         39 . A neural response process as claimed in  claim 22 , wherein the biomarker data is used to differentiate a diagnosis between conditions having similar symptoms. 
     
     
         40 . A neural response process as claimed in  claim 39 , wherein the conditions are benign positional paroxysmal vertigo (BPPV) and Meniere's disease. 
     
     
         41 . A neural response process as claimed in  claim 39 , wherein the conditions are clinical depression and a depressive phase of a BiPolar Affective Disorder. 
     
     
         42 . (canceled)