US2016022867A1PendingUtilityA1

Template for bacterial cellulose implant processed within bioreactor

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Assignee: SOFRADIM PRODUCTIONPriority: Nov 7, 2008Filed: Jul 22, 2015Published: Jan 28, 2016
Est. expiryNov 7, 2028(~2.3 yrs left)· nominal 20-yr term from priority
Inventors:Yves BayonSébastien LadetOlivier LefrancPhilippe Gravagna
A61L 27/50A61L 27/20A61L 27/56A61L 27/58Y10T428/24479A61F 13/00059A61F 2013/00255A61K 9/70A61F 2013/00314A61F 2013/00153A61F 13/01012A61F 13/01021
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Claims

Abstract

The present invention relates to an implant comprising: a sheet of bacterial cellulose having a macro-pattern positioned on at least a portion thereof. The invention also relates to a method for making such an implant.

Claims

exact text as granted — not AI-modified
1 - 5 . (canceled) 
     
     
         6 . An implant comprising:
 a sheet of bacterial cellulose having a macro-pattern positioned on at least a portion thereof, wherein the sheet includes pores of a size from about 0.5 to 5 mm and which do not pass completely through the sheet.   
     
     
         7 . The implant of  claim 6 , wherein the pores are from about 0.1 mm to 3 mm in size. 
     
     
         8 . The implant of  claim 6 , wherein the bacterial cellulose is derived from  Acetobacter xylinum.    
     
     
         9 . The implant of  claim 6 , wherein the bacterial cellulose is oxidized. 
     
     
         10 . The implant of  claim 9 , wherein the bacterial cellulose is oxidized with a degree of oxidation from 0.1 to 0.9. 
     
     
         11 . The implant of  claim 9 , wherein the bacterial cellulose is oxidized with a degree of oxidation from 0.2 to 0.65. 
     
     
         12 . The implant of  claim 9 , wherein the bacterial cellulose is oxidized by periodic acid or nitrogen dioxide. 
     
     
         13 . The implant of  claim 12 , wherein the bacterial cellulose is oxidized when the cellulose is at least partially purified and depyrogenated. 
     
     
         14 . The implant of  claim 6 , wherein the sheet is a generally planar film. 
     
     
         15 . The implant of  claim 6 , wherein the implant is bioresorbable. 
     
     
         16 . The implant of  claim 6 , wherein the pores comprise a shape selected from the group consisting of circular, conical, rectangular, square, oval, and, elliptical. 
     
     
         17 . The implant of  claim 6 , wherein the pores are regularly distributed circular openings. 
     
     
         18 . The implant of  claim 6 , wherein the sheet is sterilized. 
     
     
         19 . A bioresorbable implant comprising:
 a sheet of bacterial cellulose which includes a first surface which allows tissue integration and includes a macro-pattern positioned on at least a portion thereof which includes pores which do not pass completely through the sheet, and a second continuous, not indented surface for the prevention of post-operative adhesions.   
     
     
         20 . The bioresorbable implant of  claim 19 , wherein the pores are from about 0.5 mm to 5 mm in size. 
     
     
         21 . The bioresorbable implant of  claim 19 , wherein the pores are from about 0.1 mm to 3 mm in size. 
     
     
         22 . The bioresorbable implant of  claim 19 , wherein the bacterial cellulose is derived from  Acetobacter xylinum.    
     
     
         23 . The bioresorbable implant of  claim 19 , wherein the bacterial cellulose is oxidized. 
     
     
         24 . The bioresorbable implant of  claim 23 , wherein the bacterial cellulose is oxidized with a degree of oxidation from 0.1 to 0.9. 
     
     
         25 . The bioresorbable implant of  claim 23 , wherein the bacterial cellulose is oxidized by periodic acid or nitrogen dioxide.

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