US2016022762A1PendingUtilityA1

Agent for Eliminating Multidrug Resistance

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Individually held — no corporate assignee on recordPriority: Nov 25, 2008Filed: Sep 14, 2015Published: Jan 28, 2016
Est. expiryNov 25, 2028(~2.3 yrs left)· nominal 20-yr term from priority
Inventors:Vasiliy V. Lebedev
C07K 7/06A61K 38/08A61K 45/06A61K 9/08A61P 35/00A61P 31/00A61P 43/00A61K 9/02A61K 9/0019
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Claims

Abstract

The invention belongs to medicine, namely to pharmacology, and may be used to overcome multiple drug resistance in oncological and infectious patients undergoing long-term chemotherapy. Essence of the invention: proposed herein as a therapeutic agent intended to overcome multiple drug resistance is a hexapeptide with the following structural formula: lysyl-histidyl-glycyl-lysyl-histidyl-glycine.

Claims

exact text as granted — not AI-modified
1 . A method for preventing or treating multiple drug resistance in a patient comprising administering an effective amount of a therapeutic agent comprising a hexapeptide with the following structural formula: lysyl-histidyl-glycyl-lysyl-histidyl-glycine (SEQ ID NO: 1) and a target additive prior to and during chemoradiotherapy. 
     
     
         2 . The method according to  claim 2 , wherein the therapeutic agent is manufactured in the form of a solution for subcutaneous and intramuscular injections and contains aminoacetic acid as a target additive. 
     
     
         3 . The method according to  claim 2 , wherein the therapeutic agent is made in the form of a spray intended for dosed application and contains aminoacetic acid and benzalkonium chloride as target additives. 
     
     
         4 . The method according to  claim 2 , wherein the therapeutic agent is made in the form of a suppository containing aminoacetic acid, Tween 80 (Polysorbate 80), water for injections, and hard fat as target additives.

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