CXCR4 Antagonists for the Treatment of Medical Disorders

Abstract

The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative conditions mediated by CXCR4 receptors. The compounds provided interfere with the binding of SDF1 to the receptor. These compounds are particularly useful for treating or reducing the severity of hyperproliferative diseases by inhibiting metastasis.

1 . A method of reductive amination comprising mixing a dialdehyde and an amine with a reducing agent under conditions such that the compound having the formula: 
       
         
           
           
               
               
           
         
       
       is formed. 
     
     
         2 . The method of  claim 1 , wherein the reducing agent is sodium triacetoxyborohydride. 
     
     
         3 . A method of  claim 1 , further comprising the step of comprising mixing a carboxylic acid and a compound the formula: 
       
         
           
           
               
               
           
         
       
       to form a salt. 
     
     
         4 . The method of  claim 3 , wherein the carboxylic acid is tartaric acid.