US2016000816A1PendingUtilityA1

Pharmaceutical composition, methods for treating and uses thereof

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Assignee: BOEHRINGER INGELHEIM INTPriority: Apr 5, 2013Filed: Sep 16, 2015Published: Jan 7, 2016
Est. expiryApr 5, 2033(~6.7 yrs left)· nominal 20-yr term from priority
Inventors:Uli Christian BroedlOdd-Erik JohansenGabriel Woojai KimEric Williams MayouxAfshin SalsaliNima SoleymanlouMaximilian Von EynattenHans-Juergen WoerleDavid Z.I. CherneyBruce A. PerkinsAndreas DaiberThomas Muenzel
A61K 9/0053A61K 31/7048A61K 9/2866A61K 9/2018
54
PatentIndex Score
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Claims

Abstract

The present invention relates to certain SGLT-2 inhibitors for treating and/or preventing oxidative stress, for example in patients with type 1 or type 2 diabetes, as well as to the use of such SGLT-2 inhibitors in treatment and/or prevention of cardiovascular diseases in patients, for example type 1 or type 2 diabetes patients. The present invention further relates to certain SGLT-2 inhibitors for treating and/or preventing a metabolic disorder and preventing, reducing the risk of or delaying the occurrence of a cardiovascular event in patients, for example patients with type 1 or type 2 diabetes.

Claims

exact text as granted — not AI-modified
1 . A method to reduce the risk of cardiovascular death in a patient with type 2 diabetes mellitus, said method comprising administering empagliflozin to the patient. 
     
     
         2 . The method according to  claim 1 , wherein said patient has or is at risk of a cardiovascular disease. 
     
     
         3 . The method according to  claim 1 , wherein empagliflozin is administered orally in a total daily amount of 10 mg or 25 mg. 
     
     
         4 . A method to reduce the risk of hospitalization for heart failure in a patient with type 2 diabetes mellitus, said method comprising administering empagliflozin to the patient. 
     
     
         5 . The method according to  claim 4 , wherein said patient has or is at risk of a cardiovascular disease. 
     
     
         6 . The method according to  claim 4 , wherein empagliflozin is administered orally in a total daily amount of 10 mg or 25 mg. 
     
     
         7 . A method to reduce the risk of all-cause mortality in a patient with type 2 diabetes mellitus, said method comprising administering empagliflozin to the patient. 
     
     
         8 . The method according to  claim 7 , wherein said patient has or is at risk of a cardiovascular disease. 
     
     
         9 . The method according to  claim 7 , wherein empagliflozin is administered orally in a total daily amount of 10 mg or 25 mg. 
     
     
         10 . A method to reduce the risk of all-cause mortality by reducing cardiovascular death in a patient with type 2 diabetes mellitus, said method comprising administering empagliflozin to the patient. 
     
     
         11 . The method according to  claim 10 , wherein said patient has or is at risk of a cardiovascular disease. 
     
     
         12 . The method according to  claim 10 , wherein empagliflozin is administered orally in a total daily amount of 10 mg or 25 mg.

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