Methods of Using C-Met Modulators

Abstract

Methods of treating cancer by administering a compound of Formula I, or a pharmaceutically acceptable salt or solvate thereof, in combination with other cancer treatments are described, wherein R 1 is halo; R 2 is halo; and Q is CH or N.

1 - 15 . (canceled) 
     
     
         16 . A method of treating cancer which is astocytoma, glioblastoma, giant cell glioblastoma, gliosarcoma, and glioblastoma with oligodendroglial components, wherein the method comprises administering to a patient in need of the treatment the compound which is: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, in combination with temozolomide with radiation therapy (RT), wherein TMZ is administered to the patient in 5-180 mg dosages daily to the patient during the concurrent phase; RT is administered to the patient during the concurrent phase using 1.8-2 Gy/fraction, daily for 5 days/week for a total dose of up to 60 Gy; the compound of Formula I is administered to the patient in 25-125 mg dosages daily during the maintenance phase; and TMZ is administered to the patient in 5-180 mg dosages for 5 consecutive days and repeated every 28 days until the cancer growth is slowed down 
       
     
     
         17 . The method according to claim  1 , wherein the compound is represented by the following structure: 
       
         
           
           
               
               
           
         
       
     
     
         18 . The method according to  claim 16 , wherein the compound or a pharmaceutically acceptable salt thereof, further comprises a pharmaceutically acceptable carrier, excipient, or diluent. 
     
     
         19 . The method according to  claim 18 , wherein the concurrent phase is 6-7 weeks in duration, and the rest phase is about 4 weeks in duration; and the maintenance phase is of a duration sufficient slow down the cancer growth.