US2015359931A1PendingUtilityA1

Calcium-Mediated Effects of Coral and Methods of Use Thereof

40
Assignee: UNIV BEN GURIONPriority: Nov 19, 2007Filed: Jan 8, 2015Published: Dec 17, 2015
Est. expiryNov 19, 2027(~1.3 yrs left)· nominal 20-yr term from priority
Inventors:Razi Vago
A61P 35/00A61L 2430/40A61L 27/3687A61L 2300/412A61L 27/3847A61P 17/00A61P 19/10A61L 27/365A61L 27/3834A61K 35/28A61L 2430/06A61P 19/02A61L 27/3604A61P 19/08A61P 19/00A61L 27/3852A61L 27/3654A61L 2300/102A61L 2430/02A61K 35/614A61L 27/54
40
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

This invention is directed to coral scaffolds seeded with precursor cells in culture in the presence of a chelator and uses thereof in inducing or enhancing bone and/or cartilage formation in a subject, and kits related thereto. This invention is also directed to use of cadherin-upregulating coral for treating cancer or inhibiting cancer progression. This invention is also directed to use of aragonite or calcite-producing species for in vivo calcium release, and its application to the treatment of skin diseases, disorders or conditions.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method of inducing or enhancing bone or cartilage formation or a combination thereof in a subject comprising administering to said subject a composition comprising coral, wherein said coral is seeded with a precursor cell in culture in the presence of a chelator for a period of time sufficient to seed said precursor cell in said coral. 
     
     
         2 . The method of  claim 1 , wherein said coral is from the  Porites  species. 
     
     
         3 . The method of  claim 2 , wherein said coral is  Porites Lutea.    
     
     
         4 . The method of  claim 1 , wherein said coral is from the  Millepora  species. 
     
     
         5 . The method of  claim 4 , wherein said coral is  Millepora dichotoma.    
     
     
         6 . The method of  claim 1 , wherein said coral is from the  Acropora  species. 
     
     
         7 . The method of  claim 6 , wherein said coral is  Acropora grandis.    
     
     
         8 . The method of  claim 1 , wherein said chelator is a calcium chelator. 
     
     
         9 . The method of  claim 8 , wherein said calcium chelator is EDTA. 
     
     
         10 . The method of  claim 8 , wherein said calcium chelator is calcein. 
     
     
         11 . (canceled) 
     
     
         12 . The method of  claim 1 , wherein calcium released from said coral stimulates precursor cell seeding, bone formation, cartilage formation or a combination thereof. 
     
     
         13 . The method of  claim 1 , wherein said precursor cells are mesenchymal stem cells. 
     
     
         14 . The method of  claim 1 , wherein said coral is seeded with said precursor cell in serum-free medium. 
     
     
         15 . The method of  claim 1 , wherein said period of time sufficient to seed said precursor cells in said coral is up to 72 hours. 
     
     
         16 .- 18 . (canceled) 
     
     
         19 . The method of  claim 1 , wherein said subject has osteoporosis. 
     
     
         20 . The method of  claim 1 , wherein said subject has Paget's disease, fibrous dysplasia or osteodystrophy. 
     
     
         21 . The method of  claim 1 , wherein said subject has bone or cartilage infirmity. 
     
     
         22 . The method of  claim 1 , wherein said composition is administered to a site of bone or cartilage infirmity, or a combination thereof. 
     
     
         23 . The method of  claim 1 , wherein said enhancing bone or cartilage formation comprises healing non-union fractures. 
     
     
         24 . A kit for bone formation comprising coral, bone or cartilage precursor or stem cells and a calcium chelator. 
     
     
         25 .- 88 . (canceled)

Join the waitlist — get patent alerts

Track US2015359931A1 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.