Novel antibacterial agents for the treatment of gram positive infections

Abstract

The present invention relates to novel lipopeptide compounds, pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The compounds of the invention are particularly useful against a variety of bacteria, including resistant strains. The compounds are useful as antibacterial agents against Clostridium difficile.

1 - 15 . (canceled) 
     
     
         16 . A method of preparing the compound 
       
         
           
           
               
               
           
         
       
       and pharmaceutically acceptable salts thereof, the method comprising:
 (a) providing the tert-butyloxycarbonyl-protected compound 
 
       
         
           
           
               
               
           
         
       
       and,
 b) removing the tert-butyloxycarbonyl protecting group of the compound of step (a). 
 
     
     
         17 . The method of  claim 16 , wherein step (b) is performed in the presence of trifluoroacetic acid, thereby producing a trifluoroacetic acid salt. 
     
     
         18 . The method of  claim 17 , further comprising step (c), wherein the trifluoroacetic acid salt of step (b) is reacted with an anion-exchange resin. 
     
     
         19 . The method of  claim 18 , wherein the anion-exchange resin is MP-Carbonate.