Non-aerosol foaming alcohol hand sanitizer

Abstract

A non-aerosol, foaming high alcohol content hand sanitizer is provided which has excellent antimicrobial activity and tolerance for organic load and excellent residual activity, as well as enhanced moisturization and skin-feel properties over currently marketed alcohol-based sanitizers. The inventive composition achieves an unexpectedly large amount of quality, stable foam even in the presence of significant quantities of skin conditioning agents through the use of novel silicone surfactants and achieves enhanced and prolonged antimicrobial efficacy through the combination of high alcohol content and activity enhancing components.

What is claimed is: 
     
         1 . A non-aerosol, foaming sanitizing composition having enhanced and prolonged antimicrobial activity, consisting of:
 a. an aliphatic alcohol consisting of ethanol, butyl alcohol, n-propyl alcohol, or isopropyl alcohol, or mixtures thereof, present in amounts ranging from about 40 wt. % up to about 85 wt. %;   b. an activity-enhancing substance consisting of (i) an aromatic alcohol consisting of phenoxyethanol, benzyl alcohol, or 1-phenoxy-2-propanol, or mixtures thereof, present in amounts ranging from about 0.1 wt. % to about 5 wt. %, or (ii) a cationic substrate binding activity-enhancing substance consisting of behentrimonium methosulfate, behenalkonium chloride, behentrimonium chloride, behenoyl PG-trimonium chloride, or behenamidopropyl PG-dimonium chloride, or mixtures thereof, present in amounts ranging from about 0.01 wt. % up to about 1 wt. %, or (iii) mixtures of both;   c. a silicone-based surfactant consisting of PEG-17 dimethicone, present in amounts ranging from about 1 wt. % to about 3 wt. %;   d. a polyquaternium compound, present in amounts ranging from about 0.1 wt. % to about 2 wt. %;   e. a humectant, present in amounts ranging from about 0.1 wt. % up to about 10 wt. %;   f. a cationic surfactant, present in amounts ranging from about 0.1 wt. % to about 5 wt. %;   g. an emollient, present in amounts ranging from about 0.01 wt. % up to about 5 wt. %; and   h. water,   wherein the composition has excellent tolerance for organic load and dilution and excellent residual antimicrobial activity.   
     
     
         2 . The composition set forth in  claim 1 , wherein the polyquaternium is polyquaternium-6 or polyquaternium-7, or mixtures thereof; wherein the humectant is glycerin, 2-methyl-1,3-propanediol, propylene glycol, ethylene glycol, butylene glycol, triethylene glycol, dipropylene glycol, tripropylene glycol, hexylene glycol, sorbitol, dimethyl isosorbide, sodium PCA, or hydrolyzed corn starch hydroxyethyl ether, or mixtures thereof; wherein the cationic surfactant is cocamidopropyl PG-dimonium chloride phosphate, coco PG-dimonium chloride, myristamidopropyl PG-dimonium chloride phosphate, linoleamidopropyl PG-dimonium chloride phosphate, or stearamidopropyl PG-dimonium chloride phosphate, or mixtures thereof; and wherein the emollient is PEG-45 palm kernel glycerides, cetyl lactate, C12-C15 alkyl benzoates, PEG-7 glyceryl cocoate, cetyl myristate, glyceryl dioleate, isopropyl myristate, lanolin, methyl laurate, PPG-9 laurate, octyl palmitate, PPG-5 lanoate, or di-PPG-3 myristyl ether adipate, or mixtures thereof. 
     
     
         3 . The composition as set forth in  claim 1 , wherein the aliphatic alcohol is present in amounts ranging from about 50 wt. % up to about 70 wt. %; wherein the aromatic alcohol is present in amounts ranging from about 0.5 wt. % up to about 3 wt. %; wherein the cationic substrate binding component is present in amounts ranging from about 0.05 wt. % up to about 0.5 wt. %; wherein the polyquaternium compound is present in amounts ranging from about 0.1 wt. % up to about 1 wt. %; wherein the humectant is present in amounts ranging from about 1.5 wt. % up to about 3.0 wt. %; wherein the cationic surfactant is present in amounts of about 1.0 wt. % up to about 3.0 wt. %; and wherein the emollient is present in an amounts ranging from about 0.01 wt. % up to about 3.0 wt. %, based upon the total weight of the components in the composition. 
     
     
         4 . A non-aerosol, foam sanitizing composition, having enhanced and prolonged antimicrobial activity, consisting of:
 a. ethanol present in an amount ranging from about 50 wt. % to about 60 wt. %;   b. a silicone-based surfactant consisting of PEG-17 dimethicone, present in a total amount ranging from about 1 wt. % to about 3 wt. %;   c. an aromatic alcohol consisting of phenoxyethanol, present in a total amount ranging from about 0.5 wt. % to about 3.0 wt. %;   d. a cationic substrate binding activity-enhancing substance consisting of behentrimonium methosulfate or behenalkonium chloride, present in an amount ranging from about 0.05 wt. % to about 0.5 wt. %;   e. a polyquaternium compound consisting of polyquaternium-6, present in an amount ranging from about 0.1 wt. % to about 1.0 wt. %;   f. a humectant consisting of glycerin, 2-methyl-1,3-propanediol, or mixtures thereof, present in a total amount ranging from about 1.5 wt. % up to about 3.0 wt. %;   g. a cationic surfactant consisting of cocamidopropyl PG-dimonium chloride phosphate or coco PG-dimonium chloride, present in an amount ranging from about 0.1 wt. % up to about 5.0 wt. %;   h. poloxamer 188, present in an amount of at least about 0.45 wt. %; and   i. water up to 100 wt. %,   based upon the total weight of the components of the composition.   
     
     
         5 . A non-aerosol, foaming alcohol-based hand sanitizer, consisting of:
 a. ethanol, present in amounts/ranging from about 50 to about 70 wt. %;   b. PEG-17 dimethicone, present in amounts ranging from about 1 to about 3 wt. %;   c. phenoxyethanol, present in amounts ranging from about 0.5 to about 3 wt. %;   d. behenalkonium chloride, present in amounts ranging from about 0.05 to about 0.5 wt. %;   e. polyquaternium 6, present in amounts ranging from about 0.1 to about 10 wt. %;   f. 2-methyl-1,3-propanediol and glycerin as humectants, present in a total amount ranging from about 1.5 to about 3 wt. %;   g. cocamidopropyl PG-dimonium chloride phosphate, present in amounts ranging from about 0.1 wt. % to about 5 wt. %;   g. cocamidopropyl PG-dimonium chloride phosphate, present in amounts ranging from about 0.1 wt. % to about 5 wt. %;   h. poloxamer 188; and   i. water,   wherein the composition has enhanced and prolonged antimicrobial activity, excellent tolerance for organic load and dilution, and excellent residual antimicrobial activity.   
     
     
         6 . A non-aerosol, foaming alcohol-based hand sanitizer, consisting of:
 a. ethanol;   b. PEG-17 dimethicone;   c. phenoxyethanol;   d. behentrimonium methosulfate;   e. 2-methyl-1,3-propanediol and glycerin as humectants;   g. polyquaternium-6; and;   h. water,   wherein the composition has enhanced and prolonged antimicrobial activity, excellent tolerance for organic load and dilution, and excellent residual antimicrobial activity.   
     
     
         7 . A non-aerosol, foaming alcohol-based hand sanitizer, consisting of:
 a. ethanol;   b. PEG-17;   c. an activity-enhancing substance consisting of phenoxyethanol and behentrimonium methosulfate;   d. one or more humectants;   e. a cationic surfactant;   f. one or more emollients; and   g. water,   wherein the composition has enhanced and prolonged antimicrobial activity, excellent tolerance for organic load and dilution, and excellent residual antimicrobial activity.