Contrast agent for optical imaging, use thereof and apparatus using the same

Abstract

Provided are a contrast agent for optical imaging, a use thereof and an apparatus using the same. The contrast agent for optical imaging of the present disclosure allows optical imaging without requiring a fluorophore or a luminophore. As a result, the optical images can be acquired without changing the physicochemical properties of a substrate. The contrast agent for optical imaging of the present disclosure may be used as an optical/nuclear bimodal imaging contrast agent for many applications, and allows radiation therapy as well as monitoring of a therapeutic effect thereof through optical imaging at the same time. Further, when a fluorophore is attached thereto, light emission may be enhanced without energy input from outside since light is emitted from the fluorophore, thereby increasing luminescence intensity and improving tissue penetration.

1 . A radionuclide detection apparatus for detecting the radionuclide according to  claim 1  labeled at a subject existing in a fluid flowing in a tube, comprising: a chamber through which the tube penetrates; a conversion means provided in the chamber and converting the energy of a charged particle emitted from the radionuclide into light; and a light detection means detecting the light converted by the conversion means. 
     
     
         2 . The radionuclide detection apparatus according to  claim 1 , wherein the tube penetrating the chamber has a light transmitting portion.