US2015315218A1PendingUtilityA1

Salts of prodrugs of piperazine and substituted piperidine antiviral agents

Assignee: BRISTOL MYERS SQUIBB COPriority: Mar 15, 2004Filed: Jul 15, 2015Published: Nov 5, 2015

Est. expiryMar 15, 2024(expired)· nominal 20-yr term from priority

Inventors:Yasutsugu Ueda Timothy P. Connolly John F. Kadow Nicholas A. Meanwell Tao Wang Chung-Pin H. Chen Kap-Sun Yeung Zhongxing Zhang David K. Leahy Shawn K. Pack Nachimuthu Soundararajan Pierre Sirard Kathia Levesque Dominique Thoraval

A61P 31/18A61P 31/12A61P 43/00C07D 471/04C07F 9/65515C07F 9/5728A61K 31/497C07F 9/65586C07F 9/062A61K 31/519A61K 31/675C07F 9/6561A61K 45/06C07C 215/10C07F 9/09

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Claims

Abstract

This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection: wherein: X is C or N with the proviso that when X is N, R 1 does not exist; W is C or N with the proviso that when W is N, R 2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of wherein: L and M are independently selected from the group consisting of C 1 -C 6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.

Claims

exact text as granted — not AI-modified

What is claimed is: 
     
         1 . The compound having the following formula: 
       
         
           
           
               
               
           
         
         wherein R═Na.

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