US2015313867A1PendingUtilityA1

Anti-tumoural effects of cannabinoid combinations

43
Assignee: GW PHARMA LTDPriority: Jun 4, 2008Filed: Jan 14, 2015Published: Nov 5, 2015
Est. expiryJun 4, 2028(~1.9 yrs left)· nominal 20-yr term from priority
Inventors:Guillermo Velasco DiezManuel Guzman PastorMar LorenteSofia TorresFatima Rodriguez
A61P 35/00A61K 45/06A61K 31/658A61K 31/352A61K 31/05A61K 31/353
43
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Claims

Abstract

The invention relates to the use of a combination of cannabinoids, particularly tetrahydrocannabinol (THC) and cannabidiol (CBD), in the manufacture of a medicament for use in the treatment of cancer. In particular the cancer to be treated is a brain tumour, more particularly a glioma, more particularly still a glioblastoma multiforme (GBM).

Claims

exact text as granted — not AI-modified
1 . (canceled) 
     
     
         2 . A method for treating an infiltrative tumor in a human in need thereof consisting essentially of administering to the human in need thereof therapeutically effective amounts of tetrahydrocannabinol (THC) and cannabidiol (CBD). 
     
     
         3 . The method according to  claim 2 , wherein the THC and CBD are in a ratio of from between 20:1 to 1:20 (THC:CBD). 
     
     
         4 . The method according to  claim 2 , wherein the THC and CBD are in a ratio of approximately 1:1. 
     
     
         5 . The method according to  claim 2 , wherein the cannabinoid content is in the range of between 5 and 100 mg of the total cannabinoids present. 
     
     
         6 . The method according to  claim 2 , wherein each cannabinoid is used in an amount which would be considered sub-optimal if being used alone. 
     
     
         7 . The method according to  claim 2 , wherein the cancer to be treated is a brain tumour. 
     
     
         8 . The method according to  claim 7 , wherein the brain tumour is a glioma tumour. 
     
     
         9 . The method according to  claim 8 , wherein the brain tumour is a glioblastoma multiforme (GBM). 
     
     
         10 . The method according to  claim 2 , wherein the THC and CBD are present as plant extracts, as pure compounds, or a combination of the two. 
     
     
         11 . The method according to  claim 10 , wherein the plant extract is in the form of a botanical drug substance. 
     
     
         12 . The method according to  claim 2 , wherein the THC and CBD are administered separately, sequentially or simultaneously to one another.

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