Novel Compositions and Methods for Treating Cancer

Abstract

Provided herein are methods and compositions inter alia for treating diseases, including hyperproliferative diseases, migraine headaches, and depression.

1 .- 20 . (canceled) 
     
     
         21 . A method of treating cancer in a patient in need of such treatment, said method comprising administering a therapeutically effective amount of a compound having the formula: 
       
         
           
           
               
               
           
         
         wherein 
         R 1A  is independently hydrogen, 
       
       halogen, —CX 1A   3 , —C(O)R 7A , —C(O)—OR 7A , —C(O)NR 7A R 8A , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
 R 2A  is independently hydrogen, 
 
       halogen, —CX 2A   3 , —C(O)R 9A , —C(O)—OR 9A , —C(O)NR 9A R 10A , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
 R 1A  and R 2A  are optionally joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; 
 R 3  is independently hydrogen, halogen, —CX 3   3 , —CN, —SO 2 Cl, —SO 1 R 14 , —SO k NR 11 R 12 , —NHNH 2 , —ONR 11 R 12 , —NHC═(O)NHNH 2 , 
 
       —NHC═(O)NR 11 R 12 , —N(O) m , —NR 11 R 12 , —C(O)R 13 , —C(O)—OR 13 , —O—C(O)—R 13 , —C(O)NR 11 R 12 , —NR 11 C(O)R 13 , —OR 14 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
 R 7A , R 8A , R 9A , R 10A , R 11 , R 12 , R 13 , and R 14  are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; 
 A 1  is independently ═N— or ═CR 3 —; 
 k and m are independently 1 or 2; 
 n is independently an integer from 0 to 4; 
 z1 is independently an integer from 0 to 3; and 
 X 1A , X 2A , and X 3  are independently —Cl, —Br, —I, or —F. 
 
     
     
         22 . The method of  claim 21  having the formula: 
       
         
           
           
               
               
           
         
       
     
     
         23 . The method of  claim 21  having the formula: 
       
         
           
           
               
               
           
         
       
     
     
         24 . The method of  claim 21 , wherein
 R 1A  is independently hydrogen, unsubstituted alkyl, —C(O)R 7A  or —C(O)—OR 7A ; and   R 7A  is independently hydrogen, substituted or unsubstituted C 1 -C 20  alkyl, substituted or unsubstituted 2 to 20 membered heteroalkyl, substituted or unsubstituted C 3 -C 8  cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocycloalkyl, substituted or unsubstituted C 6 -C 10  aryl, or substituted or unsubstituted 5 to 10 membered heteroaryl.   
     
     
         25 . The method of  claim 21 , wherein
 R 2A  is independently hydrogen, unsubstituted alkyl, —C(O)R 9A  or —C(O)—OR 9A ; and   R 9A  is independently hydrogen, substituted or unsubstituted C 1 -C 20  alkyl, substituted or unsubstituted 2 to 20 membered heteroalkyl, substituted or unsubstituted C 3 -C 8  cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocycloalkyl, substituted or unsubstituted C 6 -C 10  aryl, or substituted or unsubstituted 5 to 10 membered heteroaryl.   
     
     
         26 . The method of  claim 21 , wherein R 3  is independently hydrogen, halogen, —C(O)R 13 , —O—C(O)—R 13 , —C(O)—OR 13 , —OR 14 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl. 
     
     
         27 . The method of  claim 21 , wherein
 R 3  is independently hydrogen or —OR 14 ; and   R 14  is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.   
     
     
         28 . The method of  claim 27 , wherein R 14  is independently hydrogen, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl. 
     
     
         29 . The method of  claim 27 , wherein R 14  is independently substituted or unsubstituted alkyl. 
     
     
         30 . The method of  claim 27 , wherein R 14  is independently substituted or unsubstituted C 1 -C 20  alkyl. 
     
     
         31 . The method of  claim 27 , wherein R 14  is independently substituted or unsubstituted C 6 -C 16  alkyl. 
     
     
         32 . The method of  claim 27 , wherein R 14  is independently unsubstituted C 6 -C 16  alkyl. 
     
     
         33 . The method of  claim 21 , wherein A 1  is ═CR 3 —. 
     
     
         34 . The method of  claim 21 , wherein A 1  is ═N—. 
     
     
         35 . The method of  claim 21 , wherein A 1  is ═CH—. 
     
     
         36 . The method of  claim 21 , wherein the compound is: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
         37 . The method of  claim 21 , wherein said cancer is breast cancer, ovarian cancer, pancreatic cancer, liver cancer, glioblastoma, glioma, lung cancer, prostate cancer, leukemia, or melanoma. 
     
     
         38 . The method of  claim 21 , wherein said cancer is breast cancer. 
     
     
         39 . The method of  claim 21 , wherein said cancer is metastatic cancer. 
     
     
         40 . The method of  claim 21 , wherein said compound is co-administered with a chemotherapeutic agent.