Method for producing 4-oxoquinoline compound

Abstract

The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, for example, a compound represented by the formula (2′): wherein R is a fluorine atom or a methoxy group, and R 400 is a hydrogen atom or a C 1 -C 4 alkyl group, or a salt thereof, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.

1 - 33 . (canceled) 
     
     
         34 . A compound of the following formula (7): 
       
         
           
           
               
               
           
         
         wherein R 100  is a C 1 -C 4  alkyl group and R 200  is a hydroxyl-protecting group. 
       
     
     
         35 . A compound of the following formula (6) 
       
         
           
           
               
               
           
         
         wherein R is a fluorine atom or a methoxy group, and R 100  is a C 1 -C 4  alkyl group. 
       
     
     
         36 . A compound of the following formula (5): 
       
         
           
           
               
               
           
         
         wherein R is a fluorine atom or a methoxy group, and R 100  is a C 1 -C 4  alkyl group. 
       
     
     
         37 . A compound of the following formula (4): 
       
         
           
           
               
               
           
         
         wherein R is a fluorine atom or a methoxy group, and R 100  is a C 1 -C 4  alkyl group, 
       
       or a salt thereof. 
     
     
         38 . A compound of the following formula (4-1-B): 
       
         
           
           
               
               
           
         
         wherein R 100  is a C 1 -C 4  alkyl group, 
       
       or a salt thereof. 
     
     
         39 . A compound of the following formula (4-2-B): 
       
         
           
           
               
               
           
         
         wherein R 100  is a C 1 -C 4  alkyl group, 
       
       or a salt thereof. 
     
     
         40 . A compound of the following formula (4-1-A): 
       
         
           
           
               
               
           
         
         wherein R 100  is a C 1 -C 4  alkyl group, 
       
       or a salt thereof. 
     
     
         41 . A compound of the following formula (4-2-A): 
       
         
           
           
               
               
           
         
         wherein R 100  is a C 1 -C 4  alkyl group, 
       
       or a salt thereof. 
     
     
         42 . A compound of the following formula (3): 
       
         
           
           
               
               
           
         
         wherein R is a fluorine atom or a methoxy group. 
       
     
     
         43 . A compound of the following formula (2′): 
       
         
           
           
               
               
           
         
         wherein R is a fluorine atom or a methoxy group, and R 400  is a hydrogen atom or a C 1 -C 4  alkyl group, 
       
       or a salt thereof. 
     
     
         44 . A compound of the following formula: