Composition and methods of treatment of bacterial meningitis

Abstract

A diluted solution of ceftiofur sodium is intrathecally or ventricularly delivered to effectively treat bacterial meningitis while maintaining the patient's threshold and reducing the likelihood of seizure.

What is claimed is: 
     
         1 . A composition consisting essentially of ceftiofur sodium diluted with a buffer in solution to a concentration effective to kill or inhibit the growth of bacteria that cause bacterial meningitis while avoiding seizures in humans. 
     
     
         2 . The composition of  claim 1  wherein the concentration is about 3 mg/ml. 
     
     
         3 . The composition of  claim 1  wherein the buffer comprises one of phosphate buffered saline and ringers lactate solution. 
     
     
         4 . A method for treating bacterial meningitis, comprising: providing a composition consisting essentially of ceftiofur sodium buffered in solution to a concentration of about 3 mg/ml; and injecting the composition into the intrathecal or ventricular spaces of the central nervous system. 
     
     
         5 . A method for preventing bacterial meningitis, comprising: providing a composition consisting of buffered ceftiofur sodium solution with a concentration of 3 mg/ml; and placing the composition into a surgical site. 
     
     
         6 . The method of claim further comprising the step of administering prednisolone sodium succinate to stabilize the blood brain barrier. 
     
     
         7 . The method of  claim 4  further comprising the step of administering a nonsteroidal anti-inflammatory drug. 
     
     
         8 . The method of  claim 4  further comprising the step of administering an antibiotic outside the blood brain barrier to treat systemic infections. 
     
     
         9 . The method of claim wherein the steps are repeated at least twice. 
     
     
         10 . The method of  claim 5  further comprising the step of administering prednisolone sodium succinate to stabilize the blood brain barrier. 
     
     
         11 . The method of  claim 5  further comprising the step of administering a nonsteroidal anti-inflammatory drug. 
     
     
         12 . The method of  claim 5  further comprising the step of administering an antibiotic outside the blood brain barrier to treat systemic infections. 
     
     
         13 . The method of  claim 5  further comprising the step of placing the composition into the surgical site a second time.