Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use

Abstract

The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

1 . Compound of the formula (I) 
       
         
           
           
               
               
           
         
         in which 
         A represents CH 2 , CD 2  or CH(CH 3 ), 
         R 1  represents (C 4 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl or phenyl,
 where (C 4 -C 6 )-alkyl may be substituted up to six times by fluorine, 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 to 4 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl and (C 1 -C 4 )-alkyl, 
 and 
 where phenyl may be substituted by 1 to 4 substituents independently of one another selected from the group consisting of halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 6 )-cycloalkyl, (C 1 -C 4 )-alkoxy, difluoromethoxy and trifluoromethoxy, 
 
         R 2  represents hydrogen, (C 1 -C 4 )-alkyl, cyclopropyl, monofluoromethyl, difluoromethyl or trifluoromethyl, 
         R 3  represents a group of the formula 
       
       
         
           
           
               
               
           
         
         where
 * represents the point of attachment to the carbonyl group, 
 L 1A  represents a bond or (C 1 -C 4 )-alkanediyl,
 where (C 1 -C 4 )-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 L 1B  represents a bond or (C 1 -C 4 )-alkanediyl, 
 L 1C  represents a bond or (C 1 -C 4 )-alkanediyl,
 where (C 1 -C 4 )-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 R 7  represents hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 3 -C 7 )-cycloalkyl, cyano, 5- to 10-membered heteroaryl, naphthyl or phenyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl, (C 1 -C 4 )-alkylsulphonyl, phenyl, phenoxy and benzyloxy,
 where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen or (C 1 -C 4 )-alkoxy substituents, 
 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxy, 
 and 
 where phenyl and 5- to 10-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, nitro, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, —NH(CO)CH 3 , (C 1 -C 4 )-alkyl, (C 1 -C 4 )-cycloalkyl, (C 1 -C 4 )-alkenyl, (C 1 -C 4 )-alkylsulphonyl, (C 1 -C 4 )-alkoxycarbonyl and (C 1 -C 4 )-alkoxy, 
 where (C 1 -C 4 )-alkoxy may be substituted by hydroxy, 
 and 
 in which 2 adjacent carbon atoms of the phenyl may be substituted by a difluoromethylenedioxy bridge, 
 
 R 8  represents hydrogen or (C 1 -C 4 )-alkyl, 
 or 
 R 7  and R 8  together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle, where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine and (C 1 -C 4 )-alkyl, 
 R 9  represents hydrogen, cyano, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 3 -C 7 )-cycloalkyl, 5- to 10-membered heteroaryl or phenyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, cyano, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl, (C 1 -C 4 )-alkylsulphonyl, 5- or 6-membered heteroaryl, phenyl, phenoxy and benzyloxy,
 where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen or (C 1 -C 4 )-alkoxy substituents, 
 where 5- or 6-membered heteroaryl may be benzo-fused or substituted by a 5- or 6-membered heteroaryl, 
  where 5- or 6-membered heteroaryl may be substituted by (C 1 -C 4 )-alkyl or trifluoromethyl, 
 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxy, 
 and 
 where phenyl and 5- to 10-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-cycloalkyl, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl and (C 1 -C 4 )-alkylsulphonyl, 
 where (C 1 -C 4 )-alkoxy may be substituted by hydroxy, 
 and 
 where the phenyl may be substituted on two adjacent carbon atoms by a difluoromethylenedioxy bridge, 
 
 R 10  represents hydrogen or (C 1 -C 4 )-alkyl, 
 or 
 R 9  and R 10  together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
 where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, benzyl and (C 1 -C 4 )-alkyl, 
 
 with the proviso that the radicals R 7  and R 9  do not both simultaneously represent phenyl, 
 or 
 R 7  and R 9  together with the carbon atoms to which they are attached and the group L 1B  form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
 where the 3- to 7-membered carbocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of (C 1 -C 4 )-alkyl, fluorine, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 with the proviso that not more than one of the radical pairs R 7  and R 8 , R 9  and R 10  and R 7  and R 9 , respectively, simultaneously forms a carbo- or heterocycle, 
 R 11  represents hydrogen or (C 1 -C 4 )-alkyl,
 where (C 1 -C 4 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 R 12  represents hydrogen, (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, phenyl or benzyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy, (C 1 -C 4 )-alkoxy and phenoxy, 
 and 
 where phenyl and benzyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen and trifluoromethyl, 
 
 or 
 R 11  and R 12  together with the nitrogen atom to which they are attached form a 4- to 7-membered azaheterocycle,
 where the 4- to 7-membered azaheterocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy, (C 1 -C 4 )-alkoxy and 4- to 7-membered heterocyclyl, 
 
 and 
 L 2  represents a bond or (C 1 -C 4 )-alkanediyl, 
 R 13  represents 5- to 9-membered azaheterocyclyl which is attached via a ring carbon atom,
 where 5- to 9-membered azaheterocyclyl may be substituted by 1 to 5 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl and benzyl, 
 and 
 where 5- to 9-membered azaheterocyclyl may be fused to a phenyl ring which for its part may be substituted by 1 or 2 substituents selected from the group consisting of halogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy and trifluoromethyl, 
 
 or 
 represents adamantyl, 
 
         R 4  represents hydrogen, 
         R 5  represents hydrogen, halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, (C 2 -C 4 )-alkenyl, (C 2 -C 4 )-alkynyl, difluoromethoxy, trifluoromethoxy, (C 1 -C 4 )-alkoxy, amino, 4- to 7-membered heterocyclyl or 5- or 6-membered heteroaryl, 
         R 6  represents hydrogen, cyano or halogen, 
         and its N-oxides, salts, solvates, salts of the N-oxides and solvates of the N-oxides and salts. 
       
     
     
         2 . Compound of the formula (I) according to  claim 1  in which
 A represents CH 2 , CD 2  or CH(CH 3 ), 
 R 1  represents phenyl,
 where phenyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C 1 -C 4 )-alkyl, 
 and 
 where phenyl is substituted by 1 to 2 substituents selected from the group consisting of (C 3 -C 6 )-cycloalkyl, (C 1 -C 4 )-alkoxy, difluoromethoxy and trifluoromethoxy, 
 
 R 2  represents hydrogen, (C 1 -C 4 )-alkyl, cyclopropyl, monofluoromethyl, difluoromethyl or trifluoromethyl, 
 R 3  represents a group of the formula 
 
       
         
           
           
               
               
           
         
         where
 * represents the point of attachment to the carbonyl group, 
 L 1A  represents a bond or (C 1 -C 4 )-alkanediyl,
 where (C 1 -C 4 )-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 L 1B  represents a bond or (C 1 -C 4 )-alkanediyl, 
 L 1C  represents a bond or (C 1 -C 4 )-alkanediyl,
 where (C 1 -C 4 )-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 R 7  represents hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 3 -C 7 )-cycloalkyl, cyano, 5- to 10-membered heteroaryl, naphthyl or phenyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl, (C 1 -C 4 )-alkylsulphonyl, phenyl, phenoxy and benzyloxy,
 where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen or (C 1 -C 4 )-alkoxy substituents, 
 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxy, 
 and 
 where phenyl and 5- to 10-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, nitro, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, —NH(CO)CH 3 , (C 1 -C 4 )-alkyl, (C 1 -C 4 )-cycloalkyl, (C 1 -C 4 )-alkenyl, (C 1 -C 4 )-alkylsulphonyl, (C 1 -C 4 )-alkoxycarbonyl and (C 1 -C 4 )-alkoxy, 
 where (C 1 -C 4 )-alkoxy may be substituted by hydroxy, 
 and 
 where the phenyl may be substituted on 2 adjacent carbon atoms by a difluoromethylenedioxy bridge, 
 
 R 8  represents hydrogen or (C 1 -C 4 )-alkyl, 
 or 
 R 7  and R 8  together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
 where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine and (C 1 -C 4 )-alkyl, 
 
 R 9  represents hydrogen, cyano, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 3 -C 7 )-cycloalkyl, 5- to 10-membered heteroaryl or phenyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, cyano, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl, (C 1 -C 4 )-alkylsulphonyl, 5- or 6-membered heteroaryl, phenyl, phenoxy and benzyloxy,
 where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen or (C 1 -C 4 )-alkoxy substituents, 
 where 5- or 6-membered heteroaryl may be benzo-fused or substituted by a 5- or 6-membered heteroaryl, 
  where 5- or 6-membered heteroaryl may be substituted by (C 1 -C 4 )-alkyl or trifluoromethyl, 
 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxy, 
 and 
 where phenyl and 5- to 10-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-cycloalkyl, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl and (C 1 -C 4 )-alkylsulphonyl, where (C 1 -C 4 )-alkoxy may be substituted by hydroxy, 
 and 
 where the phenyl may be substituted on 2 adjacent carbon atoms by a difluoromethylenedioxy bridge, 
 
 R 10  represents hydrogen or (C 1 -C 4 )-alkyl, 
 or 
 R 9  and R 10  together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
 where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, benzyl and (C 1 -C 4 )-alkyl, 
 
 with the proviso that the radicals R 7  and R 9  do not both simultaneously represent phenyl, 
 or 
 R 7  and R 9  together with the carbon atoms to which they are attached and the group L 1B  form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
 where the 3- to 7-membered carbocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of (C 1 -C 4 )-alkyl, fluorine, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 with the proviso that not more than one of the radical pairs R 7  and R 8 , R 9  and R 10  and R 7  and R 9 , respectively, simultaneously forms a carbo- or heterocycle, 
 R 11  represents hydrogen or (C 1 -C 4 )-alkyl,
 where (C 1 -C 4 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 R 12  represents hydrogen, (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, phenyl or benzyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy, (C 1 -C 4 )-alkoxy and phenoxy, 
 and 
 where phenyl and benzyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen and trifluoromethyl, 
 
 or 
 R 11  and R 12  together with the nitrogen atom to which they are attached form a 4- to 7-membered azaheterocycle,
 where the 4- to 7-membered azaheterocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy, (C 1 -C 4 )-alkoxy and 4- to 7-membered heterocyclyl, 
 
 and 
 L 2  represents a bond or (C 1 -C 4 )-alkanediyl, 
 R 13  represents 5- to 9-membered azaheterocyclyl which is attached via a ring carbon atom,
 where 5- to 9-membered azaheterocyclyl may be substituted by 1 to 5 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl and benzyl, 
 and 
 where 5- to 9-membered azaheterocyclyl may be fused to a phenyl ring which for its part may be substituted by 1 or 2 substituents selected from the group consisting of halogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy and trifluoromethyl, 
 
 or 
 represents adamantyl, 
 
         R 4  represents hydrogen, 
         R 5  represents hydrogen, halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 2 -C 4 )-alkenyl, (C 2 -C 4 )-alkynyl, (C 3 -C 6 )-cycloalkyl, difluoromethoxy, trifluoromethoxy, (C 1 -C 4 )-alkoxy, amino, 4- to 7-membered heterocyclyl or 5- or 6-membered heteroaryl, 
         R 6  represents hydrogen, cyano or halogen, 
         and its N-oxides, salts, solvates, salts of the N-oxides and solvates of the N-oxides and salts. 
       
     
     
         3 . Compound of the formula (I) according to  claim 1  in which
 A represents CH 2 , CD 2  or CH(CH 3 ), 
 R 1  represents (C 4 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl or phenyl,
 where (C 4 -C 6 )-alkyl may be substituted up to six times by fluorine, 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 to 4 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl and (C 1 -C 4 )-alkyl, 
 and 
 where phenyl may be substituted by 1 to 4 substituents independently of one another selected from the group consisting of halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy, (C 3 -C 6 )-cycloalkyl, difluoromethoxy and trifluoromethoxy, 
 
 R 2  represents hydrogen, (C 1 -C 4 )-alkyl, cyclopropyl, monofluoromethyl, difluoromethyl or trifluoromethyl, 
 R 3  represents a croup of the formula 
 
       
         
           
           
               
               
           
         
         where
 * represents the point of attachment to the carbonyl group, 
 L 1A  represents a bond or (C 1 -C 4 )-alkanediyl,
 where (C 1 -C 4 )-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 L 1B  represents a bond or (C 1 -C 4 )-alkanediyl, 
 L 1C  represents a bond or (C 1 -C 4 )-alkanediyl,
 where (C 1 -C 4 )-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 R 7  represents hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 3 -C 7 )-cycloalkyl, cyano, 5- to 10-membered heteroaryl, naphthyl or phenyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl, (C 1 -C 4 )-alkylsulphonyl, phenyl, phenoxy and benzyloxy,
 where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen or (C 1 -C 4 )-alkoxy substituents, 
 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxy, 
 and 
 where phenyl and 5- to 10-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, nitro, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, —NH(CO)CH 3 , (C 1 -C 4 )-alkyl, (C 1 -C 4 )-cycloalkyl, (C 1 -C 4 )-alkenyl, (C 1 -C 4 )-alkylsulphonyl, (C 1 -C 4 )-alkoxycarbonyl, and (C 1 -C 4 )-alkoxy, 
 where (C 1 -C 4 )-alkoxy may be substituted by hydroxy, 
 and 
 where the phenyl may be substituted on 2 adjacent carbon atoms by a difluoromethylenedioxy bridge, 
 
 R 8  represents hydrogen or (C 1 -C 4 )-alkyl, 
 or 
 R 7  and R 8  together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
 where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine and (C 1 -C 4 )-alkyl, 
 
 R 9  represents hydrogen, cyano, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 3 -C 7 )-cycloalkyl, 5- to 10-membered heteroaryl or phenyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, cyano, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl, (C 1 -C 4 )-alkylsulphonyl, 5- or 6-membered heteroaryl, phenyl, phenoxy and benzyloxy,
 where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen or (C 1 -C 4 )-alkoxy substituents, 
 where 5- or 6-membered heteroaryl may be benzo-fused or substituted by a 5- or 6-membered heteroaryl, 
  where 5- or 6-membered heteroaryl may be substituted by (C 1 -C 4 )-alkyl or trifluoromethyl, 
 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxy, 
 and 
 where phenyl and 5- to 10-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-cycloalkyl, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl and (C 1 -C 4 )-alkylsulphonyl, 
 where (C 1 -C 4 )-alkoxy may be substituted by hydroxy, 
 and 
 where phenyl may be substituted on 2 adjacent carbon atoms by a difluoromethylenedioxy bridge, 
 
 R 10  represents hydrogen or (C 1 -C 4 )-alkyl, 
 or 
 R 9  and R 10  together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
 where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, benzyl and (C 1 -C 4 )-alkyl, 
 
 with the proviso that the radicals R 7  and R 9  do not both simultaneously represent phenyl, 
 or 
 R 7  and R 9  together with the carbon atoms to which they are attached and the group L 1B  form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
 where the 3- to 7-membered carbocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of (C 1 -C 4 )-alkyl, fluorine, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 with the proviso that not more than one of the radical pairs R 7  and R 8 , R 9  and R 10  and R 7  and R 9 , respectively, simultaneously forms a carbo- or heterocycle, 
 R 11  represents hydrogen or (C 1 -C 4 )-alkyl,
 where (C 1 -C 4 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 R 12  represents hydrogen, (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, phenyl or benzyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy, (C 1 -C 4 )-alkoxy and phenoxy, 
 and 
 where phenyl and benzyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen and trifluoromethyl, 
 
 or 
 R 11  and R 12  together with the nitrogen atom to which they are attached form a 4- to 7-membered azaheterocycle,
 where the 4- to 7-membered azaheterocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy, (C 1 -C 4 )-alkoxy and 4- to 7-membered heterocyclyl, 
 
 and 
 L 2  represents a bond or (C 1 -C 4 )-alkanediyl, 
 R 13  represents 5- to 9-membered azaheterocyclyl which is attached via a ring carbon atom,
 where 5- to 9-membered azaheterocyclyl may be substituted by 1 to 5 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl and benzyl, 
 and 
 where 5- to 9-membered azaheterocyclyl may be fused to a phenyl ring which for its part may be substituted by 1 or 2 substituents selected from the group consisting of halogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy and trifluoromethyl, 
 
 or 
 represents adamantyl, 
 
         R 4  represents hydrogen, 
         R 5  represents monofluoromethyl, difluoromethyl, trifluoromethyl, (C 2 -C 4 )-alkenyl, (C 2 -C 4 )-alkynyl, (C 3 -C 6 )-cycloalkyl, difluoromethoxy, trifluoromethoxy, (C 1 -C 4 )-alkoxy, amino, 4- to 7-membered heterocyclyl or 5- or 6-membered heteroaryl, 
         R 6  represents hydrogen, cyano or halogen, 
         and its N-oxides, salts, solvates, salts of the N-oxides and solvates of the N-oxides and salts. 
       
     
     
         4 . Compound of the formula (I) according to  claim 1  in which
 A represents CH 2 , CD 2  or CH(CH 3 ), 
 R 1  represents (C 4 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl or phenyl,
 where (C 4 -C 6 )-alkyl may be substituted up to six times by fluorine, 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 to 4 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl and (C 1 -C 4 )-alkyl, 
 and 
 where phenyl may be substituted by 1 to 4 substituents independently of one another selected from the group consisting of halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy, (C 3 -C 6 )-cycloalkyl, difluoromethoxy and trifluoromethoxy, 
 
 R 2  represents hydrogen, (C 1 -C 4 )-alkyl, cyclopropyl, monofluoromethyl, difluoromethyl or trifluoromethyl, 
 R 3  represents a group of the formula 
 
       
         
           
           
               
               
           
         
         where
 * represents the point of attachment to the carbonyl group, 
 L 1A  represents a bond or (C 1 -C 4 )-alkanediyl,
 where (C 1 -C 4 )-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 L 1B  represents a bond or (C 1 -C 4 )-alkanediyl, 
 L 1C  represents a bond or (C 1 -C 4 )-alkanediyl,
 where (C 1 -C 4 )-alkanediyl may be substituted by 1 to 3 substituents independent of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 R 7  represents (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkynyl, cyano or phenyl,
 where (C 1 -C 6 )-alkyl is substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, difluoromethoxy, trifluoromethoxy and phenoxy,
 where phenoxy may be substituted by 1 to 3 halogen substituents, 
 
 where phenyl is substituted by 1 to 2 substituents independently of one another selected from the group consisting of cyano, nitro, difluoromethoxy, trifluoromethoxy, (C 1 -C 4 )-alkoxy, —NH(CO)CH 3  and (C 1 -C 4 )-alkenyl,
 where (C 1 -C 4 )-alkoxy is substituted by hydroxy, 
 
 
 R 8  represents hydrogen or (C 1 -C 4 )-alkyl, 
 R 9  represents hydrogen, cyano, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 3 -C 7 )-cycloalkyl, 5- to 10-membered heteroaryl or phenyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, cyano, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl, (C 1 -C 4 )-alkylsulphonyl, 5- or 6-membered heteroaryl, phenyl, phenoxy and benzyloxy,
 where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen or (C 1 -C 4 )-alkoxy substituents, 
 where 5- or 6-membered heteroaryl may be benzo-fused or substituted by a 5- or 6-membered heteroaryl, 
  where 5- or 6-membered heteroaryl may be substituted by (C 1 -C 4 )-alkyl or trifluoromethyl, 
 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxy, 
 and 
 where phenyl and 5- to 10-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-cycloalkyl, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl and (C 1 -C 4 )-alkylsulphonyl, 
 where (C 1 -C 4 )-alkoxy may be substituted by hydroxy, 
 and 
 where the phenyl may be substituted on 2 adjacent carbon atoms by a difluoromethylenedioxy bridge, 
 
 R 10  represents hydrogen or (C 1 -C 4 )-alkyl, 
 or 
 R 9  and R 10  together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
 where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, benzyl and (C 1 -C 4 )-alkyl, 
 
 with the proviso that the two radicals R 7  and R 9  do not both simultaneously represent phenyl, 
 R 11  represents hydrogen or (C 1 -C 4 )-alkyl,
 where (C 1 -C 4 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 R 12  represents hydrogen, (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, phenyl or benzyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy, (C 1 -C 4 )-alkoxy and phenoxy, 
 and 
 where phenyl and benzyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen and trifluoromethyl, 
 
 or 
 R 11  and R 12  together with the nitrogen atom to which they are attached form a 4- to 7-membered azaheterocycle,
 where the 4- to 7-membered azaheterocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy, (C 1 -C 4 )-alkoxy and 4- to 7-membered heterocycle, 
 
 and 
 L 2  represents a bond or (C 1 -C 4 )-alkanediyl, 
 R 13  represents 5- to 9-membered azaheterocyclyl which is attached via a ring carbon atom,
 where 5- to 9-membered azaheterocyclyl may be substituted by 1 to 5 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl and benzyl, 
 and 
 where 5- to 9-membered azaheterocyclyl may be fused to a phenyl ring which for its part may be substituted by 1 or 2 substituents selected from the group consisting of halogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy and trifluoromethyl, 
 
 or 
 represents adamantyl, 
 
         R 4  represents hydrogen, 
         R 5  represents hydrogen, halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 2 -C 4 )-alkenyl, (C 2 -C 4 )-alkynyl, (C 3 -C 6 )-cycloalkyl, difluoromethoxy, trifluoromethoxy, (C 1 -C 4 )-alkoxy, amino, 4- to 7-membered heterocyclyl or 5- or 6-membered heteroaryl, 
         R 6  represents hydrogen, cyano or halogen, 
       
       and its N-oxides, salts, solvates, salts of the N-oxides and solvates of the N-oxides and salts. 
     
     
         5 . Compound of the formula (I) according to  claim 1  in which
 A represents CH 2 , CD 2  or CH(CH 3 ), 
 R 1  represents (C 4 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl or phenyl,
 where (C 4 -C 6 )-alkyl may be substituted up to six times by fluorine, 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 to 4 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl and (C 1 -C 4 )-alkyl, 
 and 
 where phenyl may be substituted by 1 to 4 substituents independently of one another selected from the group consisting of halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy, (C 3 -C 6 )-cycloalkyl, difluoromethoxy and trifluoromethoxy, 
 
 R 2  represents hydrogen, (C 1 -C 4 )-alkyl, cyclopropyl, monofluoromethyl, difluoromethyl or trifluoromethyl, 
 R 3  represents a group of the formula 
 
       
         
           
           
               
               
           
         
         where
 * represents the point of attachment to the carbonyl group, 
 L 1A  represents a bond or (C 1 -C 4 )-alkanediyl,
 where (C 1 -C 4 )-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 L 1B  represents a bond or (C 1 -C 4 )-alkanediyl, 
 L 1C  represents a bond or (C 1 -C 4 )-alkanediyl,
 where (C 1 -C 4 )-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 R 7  represents hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 3 -C 7 )-cycloalkyl, cyano, 5- to 10-membered heteroaryl, naphthyl or phenyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl, (C 1 -C 4 )-alkylsulphonyl, phenyl, phenoxy and benzyloxy,
 where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen or (C 1 -C 4 )-alkoxy substituents, 
 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxy, 
 and 
 where phenyl and 5- to 10-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, nitro, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, —NH(CO)CH 3 , (C 1 -C 4 )-alkyl, (C 1 -C 4 )-cycloalkyl, (C 1 -C 4 )-alkenyl, (C 1 -C 4 )-alkylsulphonyl, (C 1 -C 4 )-alkoxycarbonyl, and (C 1 -C 4 )-alkoxy, 
 where (C 1 -C 4 )-alkoxy may be substituted by hydroxy, 
 and 
 where phenyl may be substituted on 2 adjacent carbon atoms by a difluoromethylenedioxy bridge, 
 
 R 8  represents hydrogen or (C 1 -C 4 )-alkyl, 
 or 
 R 7  and R 8  together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
 where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine and (C 1 -C 4 )-alkyl, 
 
 R 9  represents (C 1 -C 6 )-alkyl, cyano or phenyl,
 where (C 1 -C 6 )-alkyl is substituted by 1 to 3 substituents independently of one another selected from the group consisting of cyano, fluorine, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, 5- or 6-membered heteroaryl, phenoxy and benzyloxy,
 where phenoxy is substituted by 1 to 3 halogen substituents, 
 where benzyloxy may be substituted by 1 to 3 halogen substituents, 
 where 5- or 6-membered heteroaryl is substituted by a 5- or 6-membered heteroaryl, 
  where 5- or 6-membered heteroaryl for its part may be substituted by (C 1 -C 4 )-alkyl, 
 
 where phenyl is substituted by 1 to 2 substituents independently of one another selected from the group consisting of cyano, difluoromethoxy, trifluoromethoxy and (C 1 -C 4 )-alkoxy,
 where (C 1 -C 4 )-alkoxy is substituted by hydroxy, 
 
 
 R 10  represents hydrogen or (C 1 -C 4 )-alkyl, 
 R 11  represents hydrogen or (C 1 -C 4 )-alkyl,
 where (C 1 -C 4 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 R 12  represents hydrogen, (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, phenyl or benzyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy, (C 1 -C 4 )-alkoxy and phenoxy, 
 and 
 where phenyl and benzyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen and trifluoromethyl, 
 
 or 
 R 11  and R 12  together with the nitrogen atom to which they are attached form a 4- to 7-membered azaheterocycle,
 where the 4- to 7-membered azaheterocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy, (C 1 -C 4 )-alkoxy and 4- to 7-membered heterocyclyl, 
 
 and 
 L 2  represents a bond or (C 1 -C 4 )-alkanediyl, 
 R 13  represents 5- to 9-membered azaheterocyclyl which is attached via a ring carbon atom,
 where 5- to 9-membered azaheterocyclyl may be substituted by 1 to 5 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl and benzyl, 
 and 
 where 5- to 9-membered azaheterocyclyl may be fused to a phenyl ring which for its part may be substituted by 1 or 2 substituents selected from the group consisting of halogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy and trifluoromethyl, 
 
 or 
 represents adamantyl, 
 
         R 4  represents hydrogen, 
         R 5  represents hydrogen, halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 2 -C 4 )-alkenyl, (C 2 -C 4 )-alkynyl, (C 3 -C 6 )-cycloalkyl, difluoromethoxy, trifluoromethoxy, (C 1 -C 4 )-alkoxy, amino, 4- to 7-membered heterocyclyl or 5- or 6-membered heteroaryl, 
         R 6  represents hydrogen, cyano or halogen, 
         and its N-oxides, salts, solvates, salts of the N-oxides and solvates of the N-oxides and salts. 
       
     
     
         6 . Compound of the formula (I) according to  claim 1  in which
 A represents CH 2 , CD 2  or CH(CH 3 ), 
 R 1  represents (C 4 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl or phenyl,
 where (C 4 -C 6 )-alkyl may be substituted up to six times by fluorine, 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 to 4 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl and (C 1 -C 4 )-alkyl, 
 and 
 where phenyl may be substituted by 1 to 4 substituents independently from one another selected from the group consisting of halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy, (C 3 -C 6 )-cycloalkyl, difluoromethoxy and trifluoromethoxy, 
 
 R 2  represents hydrogen, (C 1 -C 4 )-alkyl, cyclopropyl, monofluoromethyl, difluoromethyl or trifluoromethyl, 
 R 3  represents a group of the formula 
 
       
         
           
           
               
               
           
         
         where
 * represents the point of attachment to the carbonyl group, 
 L 1A  represents a bond or (C 1 -C 4 )-alkanediyl,
 where (C 1 -C 4 )-alkanediyl may be substituted by 1 to 3 substituents independently from one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 L 1B  represents a bond or (C 1 -C 4 )-alkanediyl, 
 L 1C  represents a bond or (C 1 -C 4 )-alkanediyl,
 where (C 1 -C 4 )-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 R 7  represents hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 3 -C 7 )-cycloalkyl, cyano, 5- to 10-membered heteroaryl, naphthyl or phenyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl, (C 1 -C 4 )-alkylsulphonyl, phenyl, phenoxy and benzyloxy,
 where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen or (C 1 -C 4 )-alkoxy substituents, 
 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxy, 
 and 
 where phenyl and 5- to 10-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, nitro, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, —NH(CO)CH 3 , (C 1 -C 4 )-alkyl, (C 1 -C 4 )-cycloalkyl, (C 1 -C 4 )-alkenyl, (C 1 -C 4 )-alkylsulphonyl, (C 1 -C 4 )-alkoxycarbonyl and (C 1 -C 4 )-alkoxy, 
 where (C 1 -C 4 )-alkoxy may be substituted by hydroxy, 
 and 
 where the phenyl may be substituted on 2 adjacent carbon atoms by a difluoromethylenedioxy bridge, 
 
 R 8  represents hydrogen or (C 1 -C 4 )-alkyl, 
 or 
 R 7  and R 8  together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
 where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine and (C 1 -C 4 )-alkyl, 
 
 R 9  represents hydrogen, cyano, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 3 -C 7 )-cycloalkyl, 5- to 10-membered heteroaryl or phenyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, cyano, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl, (C 1 -C 4 )-alkylsulphonyl, 5- or 6-membered heteroaryl, phenyl, phenoxy and benzyloxy,
 where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen or (C 1 -C 4 )-alkoxy substituents, 
 where 5- or 6-membered heteroaryl may be benzo-fused or substituted by a 5- or 6-membered heteroaryl, 
  where 5- or 6-membered heteroaryl may be substituted by (C 1 -C 4 )-alkyl or trifluoromethyl, 
 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxy, 
 and 
 where phenyl and 5- to 10-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-cycloalkyl, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl and (C 1 -C 4 )-alkylsulphonyl,
 where (C 1 -C 4 )-alkoxy may be substituted by hydroxy, 
 
 and 
 where the phenyl may be substituted on 2 adjacent carbon atoms by a difluoromethylenedioxy bridge, 
 
 R 10  represents hydrogen or (C 1 -C 4 )-alkyl, 
 or 
 R 9  and R 10  together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
 where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, benzyl and (C 1 -C 4 )-alkyl, 
 
 with the proviso that the radicals R 7  and R 9  do not both simultaneously represent phenyl, 
 or 
 R 7  and R 9  together with the carbon atoms to which they are attached and the group L 1B  form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
 where the 3- to 7-membered carbocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of (C 1 -C 4 )-alkyl, fluorine, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 with the proviso that not more than one of the radical pairs R 7  and R 8 , R 9  and R 10  and R 7  and R 9 , respectively, simultaneously forms a carbo- or heterocycle, 
 R 11  represents (C 1 -C 4 )-alkyl,
 where (C 1 -C 4 )-alkyl is substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 R 12  represents hydrogen, (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, phenyl or benzyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy, (C 1 -C 4 )-alkoxy and phenoxy, 
 and 
 where phenyl and benzyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen and trifluoromethyl, 
 
 or 
 R 11  and R 12  together with the nitrogen atom to which they are attached form a 4- to 7-membered azaheterocycle,
 where the 4- to 7-membered azaheterocycle is substituted by 1 or 2 substituents independently from one another selected from the group consisting of (C 3 -C 7 )-cycloalkyl and 4- to 7-membered heterocyclyl, 
 
 and 
 L 2  represents a bond or (C 1 -C 4 )-alkanediyl, 
 R 13  represents 5- to 9-membered azaheterocyclyl which is attached via a ring carbon atom,
 where 5- to 9-membered azaheterocyclyl may be substituted by 1 to 5 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl and benzyl, 
 and 
 where 5- to 9-membered azaheterocyclyl may be fused to a phenyl ring which for its part may be substituted by 1 or 2 substituents selected from the group consisting of halogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy and trifluoromethyl, 
 
 or 
 represents adamantyl, 
 
         R 4  represents hydrogen, 
         R 5  represents hydrogen, halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 2 -C 4 )-alkenyl, (C 2 -C 4 )-alkynyl, (C 3 -C 6 )-cycloalkyl, difluoromethoxy, trifluoromethoxy, (C 1 -C 4 )-alkoxy, amino, 4- to 7-membered heterocyclyl or 5- or 6-membered heteroaryl, 
         R 6  represents hydrogen, cyano or halogen, 
         and its N-oxides, salts, solvates, salts of the N-oxides and solvates of the N-oxides and salts. 
       
     
     
         7 . Compound of the formula (I) according to  claim 1  in which
 A represents CH 2 , CD 2  or CH(CH 3 ), 
 R 1  represents (C 4 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl or phenyl,
 where (C 4 -C 6 )-alkyl may be substituted up to six times by fluorine, 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 to 4 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl and (C 1 -C 4 )-alkyl, 
 and 
 where phenyl may be substituted by 1 to 4 substituents independently of one another selected from the group consisting of halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy, (C 3 -C 6 )-cycloalkyl, difluoromethoxy and trifluoromethoxy, 
 
 R 2  represents hydrogen, (C 1 -C 4 )-alkyl, cyclopropyl, monofluoromethyl, difluoromethyl or trifluoromethyl, 
 R 3  represents a group of the formula 
 
       
         
           
           
               
               
           
         
         where
 * represents the point of attachment to the carbonyl group, 
 L 1A  represents a bond or (C 1 -C 4 )-alkanediyl,
 where (C 1 -C 4 )-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 L 1B  represents a bond or (C 1 -C 4 )-alkanediyl, 
 L 1C  represents a bond or (C 1 -C 4 )-alkanediyl,
 where (C 1 -C 4 )-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 R 7  represents hydrogen, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 3 -C 7 )-cycloalkyl, cyano, 5- to 10-membered heteroaryl, naphthyl or phenyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl, (C 1 -C 4 )-alkylsulphonyl, phenyl, phenoxy and benzyloxy,
 where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen or (C 1 -C 4 )-alkoxy substituents, 
 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxy, 
 and 
 where phenyl and 5- to 10-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, nitro, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, —NH(CO)CH 3 , (C 1 -C 4 )-alkyl, (C 1 -C 4 )-cycloalkyl, (C 1 -C 4 )-alkenyl, (C 1 -C 4 )-alkylsulphonyl, (C 1 -C 4 )-alkoxycarbonyl and (C 1 -C 4 )-alkoxy, 
 where (C 1 -C 4 )-alkoxy may be substituted by hydroxy, 
 and 
 where the phenyl may be substituted on 2 adjacent carbon atoms by a difluoromethylenedioxy bridge, 
 
 R 8  represents hydrogen or (C 1 -C 4 )-alkyl, 
 or 
 R 7  and R 8  together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
 where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine and (C 1 -C 4 )-alkyl, 
 
 R 9  represents hydrogen, cyano, (C 1 -C 6 )-alkyl, (C 2 -C 6 )-alkenyl, (C 2 -C 6 )-alkynyl, (C 3 -C 7 )-cycloalkyl, 5- to 10-membered heteroaryl or phenyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, cyano, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl, (C 1 -C 4 )-alkylsulphonyl, 5- or 6-membered heteroaryl, phenyl, phenoxy and benzyloxy,
 where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen or (C 1 -C 4 )-alkoxy substituents, 
 where 5- or 6-membered heteroaryl may be benzo-fused or substituted by a 5- or 6-membered heteroaryl, 
  where 5- or 6-membered heteroaryl may be substituted by (C 1 -C 4 )-alkyl or trifluoromethyl, 
 
 where (C 3 -C 7 )-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl and (C 1 -C 4 )-alkoxy, 
 and 
 where phenyl and 5- to 10-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-cycloalkyl, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkoxycarbonyl and (C 1 -C 4 )-alkylsulphonyl, 
 where (C 1 -C 4 )-alkoxy may be substituted by hydroxy, 
 and 
 where the phenyl may be substituted on 2 adjacent carbon atoms by a difluoromethylenedioxy bridge, 
 
 R 10  represents hydrogen or (C 1 -C 4 )-alkyl, 
 or 
 R 9  and R 10  together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
 where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, benzyl and (C 1 -C 4 )-alkyl, 
 
 with the proviso that the radicals R 7  and R 9  do not both simultaneously represent phenyl, 
 or 
 R 7  and R 9  together with the carbon atoms to which they are attached and the group L 1B  form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
 where the 3- to 7-membered carbocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of (C 1 -C 4 )-alkyl, fluorine, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 with the proviso that not more than one of the radical pairs R 7  and R 8 , R 9  and R 10  and R 7  and R 9 , respectively, simultaneously forms a carbo- or heterocycle, 
 R 11  represents hydrogen or (C 1 -C 4 )-alkyl,
 where (C 1 -C 4 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy and (C 1 -C 4 )-alkoxy, 
 
 R 12  represents hydrogen, (C 1 -C 6 )-alkyl, (C 3 -C 7 )-cycloalkyl, phenyl or benzyl,
 where (C 1 -C 6 )-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy, (C 1 -C 4 )-alkoxy and phenoxy, 
 and 
 where phenyl and benzyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen and trifluoromethyl, 
 
 or 
 R 11  and R 12  together with the nitrogen atom to which they are attached form a 4- to 7-membered azaheterocycle,
 where the 4- to 7-membered azaheterocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 3 -C 7 )-cycloalkyl, hydroxy, (C 1 -C 4 )-alkoxy and 4- to 7-membered heterocyclyl, 
 
 and 
 L 2  represents a bond or (C 1 -C 4 )-alkanediyl, 
 R 13  represents 5- to 9-membered azaheterocyclyl which is attached via a ring carbon atom,
 where 5- to 9-membered azaheterocyclyl is substituted by 1 to 5 substituents independently of one another selected from the group consisting of (C 3 -C 7 )-cycloalkyl and benzyl, 
 
 
         R 4  represents hydrogen, 
         R 5  represents hydrogen, halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C 1 -C 4 )-alkyl, (C 2 -C 4 )-alkenyl, (C 2 -C 4 )-alkynyl, (C 3 -C 6 )-cycloalkyl, difluoromethoxy, trifluoromethoxy, (C 1 -C 4 )-alkoxy, amino, 4- to 7-membered heterocyclyl or 5- or 6-membered heteroaryl, 
         R 6  represents hydrogen, cyano or halogen, 
         and its N-oxides, salts, solvates, salts of the N-oxides and solvates of the N-oxides and salts. 
       
     
     
         8 . Compound of the formula (I) according to  claim 1  in which
 A represents CH 2 , 
 R 1  represents phenyl,
 where phenyl is substituted by 2 to 3 fluorine, 
 
 R 2  represents methyl, 
 R 3  represents a group of the formula 
 
       
         
           
           
               
               
           
         
         where
 * represents the point of attachment to the carbonyl group, 
 L 1A  represents a bond, 
 L 1B  represents a bond, 
 L 1C  represents a bond, 
 R 7  represents hydrogen, 
 R 8  represents hydrogen, 
 R 9  represents hydrogen or (C 1 -C 4 )-alkyl, 
 R 10  represents methyl or ethyl, 
 R 11  represents hydrogen, 
 R 12  represents hydrogen, 
 
         R 4  represents hydrogen, 
         R 5  represents hydrogen or methyl, 
         R 6  represents hydrogen, 
         and the N-oxides, salts, solvates, salts of the N-oxides and solvates of the N-oxides and salts. 
       
     
     
         9 . Compound of the formula (I) according to  claim 1  in which
 A represents CH 2 , 
 R 1  represents phenyl,
 where phenyl is substituted by 2 to 3 fluorine, 
 
 R 2  represents methyl, 
 R 3  represents a group of the formula 
 
       
         
           
           
               
               
           
         
         where
 * represents the point of attachment to the carbonyl group, 
 L 1A  represents a bond, 
 L 1B  represents a bond, 
 L 1C  represents a bond, 
 R 7  represents hydrogen, 
 R 8  represents hydrogen, 
 R 9  represents (C 1 -C 4 )-alkyl, 
 where (C 1 -C 4 )-alkyl is substituted up to five times by fluorine, 
 R 10  represents methyl or ethyl, 
 R 11  represents hydrogen, 
 R 12  represents hydrogen, 
 
         R 4  represents hydrogen, 
         R 5  represents hydrogen or methyl, 
         R 6  represents hydrogen, 
         and its N-oxides, salts, solvates, salts of the N-oxides and solvates of the N-oxides and salts. 
       
     
     
         10 . Process for preparing the compounds of the formula (I) as defined in  claim 1 , wherein
 [A] a compound of the formula (II)   
       
         
           
           
               
               
           
         
         in which A, R 1 , R 2 , R 4 , R 5  and R 6  each have the meanings given above and 
         T 1  represents (C 1 -C 4 )-alkyl or benzyl, 
         is reacted in an inert solvent in the presence of a suitable base or acid to give a carboxylic acid of the formula (III) 
       
       
         
           
           
               
               
           
         
         in which A, R 1 , R 2 , R 4 , R 5  and R 6  each have the meanings given above, 
         and this is subsequently reacted in an inert solvent under amide coupling conditions with an amine of the formula (IV-A) or (IV-B) 
       
       
         
           
           
               
               
           
         
         in which L 1A , L 1B , L 1C , L 2 , R 7 , R 8 , R 9 , and R 10  each have the meanings given above 
         and 
         R 11A , R 12A  and R 13A  have the meanings given above for R 11 , R 12  and R 13 , respectively, or represent an amino protective group, for example tert-butoxycarbonyl, benzyloxycarbonyl or benzyl, 
         or 
         [B] a compound of the formula (III-B) 
       
       
         
           
           
               
               
           
         
         in which R 2 , R 4 , R 5  and R 6  each have the meanings given above, 
         is reacted in an inert solvent under amide coupling conditions with an amine of the formula (IV) to give a compound of the formula (I-A) and (I-B), 
       
       
         
           
           
               
               
           
         
         in which R 2 , R 4 , R 5 , R 6 , L 1A , L 1B , L 1C , L 2 , R 7 , R 8 , R 9 , R 10 , R 11A , R 12A  and R 13A  each have the meanings given above, 
         from this compound, the benzyl group is subsequently removed using methods known to the person skilled in the art and the resulting compound of the formula (V-A) or (V-B) 
       
       
         
           
           
               
               
           
         
         in which R 2 , R 4 , R 5 , R 6 , L 1A , L 1B , L 1C , L 2 , R 7 , R 8 , R 9 , R 10 , R 11A , R 12A  and R 13A  each have the meanings given above, 
         is reacted in an inert solvent in the presence of a suitable base with a compound of the formula (VI) 
       
       
         
           
           
               
               
           
         
         in which A and R 1  have the meanings given above and 
         X 1  represents a suitable leaving group, in particular chlorine, bromine, iodine, mesylate, triflate or tosylate, 
         any protective groups present are subsequently removed, and the resulting compounds of the formula (I) are optionally converted with the appropriate (i) solvents and/or (ii) acids or bases into their solvates, salts and/or solvates of the salts. 
       
     
     
         11 . (canceled) 
     
     
         12 . Method for the treatment and/or prophylaxis of heart failure, angina pectoris, hypertension, pulmonary hypertension, ischaemias, vascular disorders, kidney failure, thromboembolic disorders and arteriosclerosis comprising administering an effective amount of at least one compound of the formula (I) as defined in  claim 1  to a subject in need thereof. 
     
     
         13 . A pharmaceutical composition comprising a compound of the formula (I) as defined in  claim 1  in combination with an inert, non-toxic, pharmaceutically suitable auxiliary. 
     
     
         14 . A pharmaceutical composition comprising a compound of the formula (I) as defined in  claim 1  in combination with a further active compound selected from the group consisting of organic nitrates, NO donors, cGMP-PDE inhibitors, agents having antithrombotic activity, agents lowering blood pressure, and agents altering lipid metabolism. 
     
     
         15 . Method for the treatment and/or prophylaxis of heart failure, angina pectoris, hypertension, pulmonary hypertension, ischaemias, vascular disorders, kidney failure, thromboembolic disorders and arteriosclerosis comprising administering an effective amount of the pharmaceutical composition as defined in  claim 13  to a subject in need thereof. 
     
     
         16 . Method for the treatment and/or prophylaxis of heart failure, angina pectoris, hypertension, pulmonary hypertension, ischaemias, vascular disorders, kidney failure, thromboembolic disorders and arteriosclerosis comprising administering an effective amount of the pharmaceutical composition as defined in  claim 14  to a subject in need thereof. 
     
     
         17 . The method as defined in  claim 12 , wherein the subject is a human subject or an animal subject. 
     
     
         18 . The method as defined in  claim 15 , wherein the subject is a human subject or an animal subject. 
     
     
         19 . The method as defined in  claim 16 , wherein the subject is a human subject or an animal subject.