Core-shell silica nanoparticles, method for manufacturing the same, method for manufacturing hollow silica nanoparticles therefrom, and hollow silica nanoparticles manufactured thereby

Abstract

The present invention relates to a monodisperse core-shell silica nanoparticle including a core layer based on a hydrophobic organic segment (a2) portion of a copolymer (A) containing an aliphatic polyamine chain (a1) containing primary amino groups and/or secondary amino groups and the hydrophobic organic segment (a2) and a shell layer composed of a hybrid based on the aliphatic polyamine chain (a1) portion and silica (B), and also relates to a method for manufacturing such a core-shell silica nanoparticle, a method for manufacturing a hollow silica nanoparticle from such a core-shell silica nanoparticle, and a hollow silica nanoparticle manufactured by this method of manufacture.

1 . A monodisperse core-shell silica nanoparticle comprising a core layer based on a hydrophobic organic segment (a2) portion of a copolymer (A) comprising an aliphatic polyamine chain (a1) containing primary amino groups and/or secondary amino groups and the hydrophobic organic segment (a2); and a shell layer comprising a hybrid based on the aliphatic polyamine chain (a1) and silica (B). 
     
     
         2 . The core-shell silica nanoparticle according to  claim 1 , wherein the core-shell silica nanoparticle has an average particle size of 5 to 30 nm. 
     
     
         3 . The core-shell silica nanoparticle according to  claim 1 , further comprising a polysilsesquioxane. 
     
     
         4 . A method for manufacturing the core-shell silica nanoparticle according to  claim 1 , the method comprising the steps of mixing the copolymer (A) comprising the aliphatic polyamine chain (a1) containing primary amino groups and/or secondary amino groups and the hydrophobic organic segment (a2) with an aqueous medium to form an aggregate comprising a core layer based on the hydrophobic organic segment (a2) portion and a shell layer based on the aliphatic polyamine chain (a1); and performing a sol-gel reaction of a silica source using the aggregate as a template. 
     
     
         5 . A monodisperse hollow silica nanoparticle having an average particle size of 5 to 30 nm and an inner diameter of 1 to 10 nm. 
     
     
         6 . A monodisperse hollow silica nanoparticle formed by removing the copolymer (A) from the core-shell silica nanoparticle according to  claim 1 , the hollow silica nanoparticle having an average particle size of 5 to 30 nm and an inner diameter of 1 to 10 nm. 
     
     
         7 . The hollow silica nanoparticle according to  claim 5 , further comprising a polysilsesquioxane. 
     
     
         8 . A method for manufacturing the hollow silica nanoparticle according to  claim 5 , the method comprising mixing a copolymer (A) comprising an aliphatic polyamine chain (a1) containing primary amino groups and/or secondary amino groups and a hydrophobic organic segment (a2) with an aqueous medium to form an aggregate comprising a core layer based on the hydrophobic organic segment (a2) and a shell layer based on the aliphatic polyamine chain (a1); performing a sol-gel reaction of a silica source using the aggregate as a template; and removing the copolymer (A). 
     
     
         9 . A hollow silica nanoparticle manufactured by the method of manufacture according to  claim 8 . 
     
     
         10 . The core-shell silica nanoparticle according to  claim 2 , further comprising a polysilsesquioxane. 
     
     
         11 . A method for manufacturing the core-shell silica nanoparticle according to  claim 2 , the method comprising the steps of mixing the copolymer (A) comprising the aliphatic polyamine chain (a1) containing primary amino groups and/or secondary amino groups and the hydrophobic organic segment (a2) with an aqueous medium to form an aggregate comprising a core layer based on the hydrophobic organic segment (a2) portion and a shell layer based on the aliphatic polyamine chain (a1); and performing a sol-gel reaction of a silica source using the aggregate as a template. 
     
     
         12 . A method for manufacturing the core-shell silica nanoparticle according to  claim 3 , the method comprising the steps of mixing the copolymer (A) comprising the aliphatic polyamine chain (a1) containing primary amino groups and/or secondary amino groups and the hydrophobic organic segment (a2) with an aqueous medium to form an aggregate comprising a core layer based on the hydrophobic organic segment (a2) portion and a shell layer based on the aliphatic polyamine chain (a1); and performing a sol-gel reaction of a silica source using the aggregate as a template. 
     
     
         13 . A method for manufacturing the core-shell silica nanoparticle according to  claim 10 , the method comprising the steps of mixing the copolymer (A) comprising the aliphatic polyamine chain (a1) containing primary amino groups and/or secondary amino groups and the hydrophobic organic segment (a2) with an aqueous medium to form an aggregate comprising a core layer based on the hydrophobic organic segment (a2) portion and a shell layer based on the aliphatic polyamine chain (a1); and performing a sol-gel reaction of a silica source using the aggregate as a template. 
     
     
         14 . The hollow silica nanoparticle according to  claim 6 , further comprising a polysilsesquioxane. 
     
     
         15 . A method for manufacturing the hollow silica nanoparticle according to  claim 6 , the method comprising mixing a copolymer (A) comprising an aliphatic polyamine chain (a1) containing primary amino groups and/or secondary amino groups and a hydrophobic organic segment (a2) with an aqueous medium to form an aggregate comprising a core layer based on the hydrophobic organic segment (a2) and a shell layer based on the aliphatic polyamine chain (a1); performing a sol-gel reaction of a silica source using the aggregate as a template; and removing the copolymer (A). 
     
     
         16 . A method for manufacturing the hollow silica nanoparticle according to  claim 7 , the method comprising mixing a copolymer (A) comprising an aliphatic polyamine chain (a1) containing primary amino groups and/or secondary amino groups and a hydrophobic organic segment (a2) with an aqueous medium to form an aggregate comprising a core layer based on the hydrophobic organic segment (a2) and a shell layer based on the aliphatic polyamine chain (a1); performing a sol-gel reaction of a silica source using the aggregate as a template; and removing the copolymer (A). 
     
     
         17 . A method for manufacturing the hollow silica nanoparticle according to  claim 14 , the method comprising mixing a copolymer (A) comprising an aliphatic polyamine chain (a1) containing primary amino groups and/or secondary amino groups and a hydrophobic organic segment (a2) with an aqueous medium to form an aggregate comprising a core layer based on the hydrophobic organic segment (a2) and a shell layer based on the aliphatic polyamine chain (a1); performing a sol-gel reaction of a silica source using the aggregate as a template; and removing the copolymer (A). 
     
     
         18 . A hollow silica nanoparticle manufactured by the method of manufacture according to  claim 15 . 
     
     
         19 . A hollow silica nanoparticle manufactured by the method of manufacture according to  claim 16 . 
     
     
         20 . A hollow silica nanoparticle manufactured by the method of manufacture according to  claim 17 .