Treatment of keratinized tissues

Abstract

Described are methods and kits for treating a keratinized tissue condition in a subject in need thereof. The method may include conducting one or more treatment cycles on the keratinized tissue. Each treatment cycle may include contacting the keratinized tissue with an acid-activated gas-generating composition. Each treatment cycle may include contacting the keratinized tissue with an acid composition. Each treatment cycle may include allowing the acid composition and the acid-activated gas-generating composition to react effective to generate a gas at the keratinized tissue.

1 . A method for treating a keratinized tissue condition in a subject in need thereof, comprising:
 conducting one or more treatment cycles on the keratinized tissue, each treatment cycle comprising:
 contacting the keratinized tissue with an acid-activated gas-generating composition; 
 contacting the keratinized tissue with an acid composition; and 
 allowing the acid composition and the acid-activated gas-generating composition to react effective to generate a gas at the keratinized tissue. 
   
     
     
         2 . The method of  claim 1 , the keratinized tissue condition being at least partly ameliorated. 
     
     
         3 . The method of  claim 1 , the keratinized tissue condition comprising one or more of: acneiform eruptions, autoinflammatory syndromes, chronic blistering, conditions of the skin appendages, dermatitis, drug or agent eruptions, infection-related, papulosquamous hyperkeratosis, palmoplantar keratodermas, pruritis, psoriasis, conditions resulting from physical factors, or ionizing radiation-induced conditions. 
     
     
         4 . The method of  claim 1 , at least one treatment cycle comprising contacting the keratinized tissue with the acid-activated gas-generating composition before contacting the keratinized tissue with the acid composition. 
     
     
         5 . The method of  claim 4 , at least one treatment cycle comprising contacting the keratinized tissue with the acid composition before contacting the keratinized tissue with the acid-activated gas-generating composition. 
     
     
         6 . The method of  claim 1 , further comprising conducting two or more of the treatment cycles in succession on the keratinized tissue. 
     
     
         7 . The method of  claim 1 , at least one treatment cycle comprising rinsing the keratinized tissue after allowing the acid composition and the acid-activated gas-generating composition to react effective to generate the gas at the keratinized tissue. 
     
     
         8 . The method of  claim 1 , at least one treatment cycle comprising contacting the keratinized tissue with the acid composition after conducting the one or more treatment cycles on the keratinized tissue. 
     
     
         9 . The method of  claim 1 , further comprising adjusting the keratinized tissue to between a pH of about 4.5 and a pH of about 6.5 after conducting the one or more treatment cycles on the keratinized tissue. 
     
     
         10 . The method of  claim 1 , the acid-activated gas-generating composition comprising one or more gas generating agents comprising one or more of: an alkali metal carbonate, alkali earth metal carbonate, an alkali metal bicarbonate, an alkali earth metal bicarbonate, or carbonic acid. 
     
     
         11 . The method of  claim 1 , the acid composition comprising an acid comprising one or more of: lactic acid, acetic acid, formic acid, citric acid, oxalic acid, phosphoric acid, succinic acid, uric acid, or an acidic ammonium salt. 
     
     
         12 . The method of  claim 1 , the acid-activated gas-generating composition and the acid composition each independently comprising one or more of: water, aloe vera extract, panthenol, a sugar, a nonionic surfactant, a preservative, a water soluble alkali metal halide salt, a water soluble alkali earth metal salt, an ionic surfactant, a sugar, or sea trace elements 
     
     
         13 . The method of  claim 1 , the acid activated gas generating composition comprising: sodium hydrogen carbonate, a water soluble alkali metal halide salt, a water soluble alkali earth metal salt; and a sugar. 
     
     
         14 . The method of  claim 1 , the acid composition comprising citric acid, sodium chloride, magnesium chloride, dextrose, and sea trace elements. 
     
     
         15 . The method of  claim 1 , at least one of the one or more treatment cycles causing the keratinized tissue to vary in pH between an alkaline state and an acidic state. 
     
     
         16 . The method of  claim 1 , the keratinized tissue comprising a plurality of cuticles, at least one of the one or more treatment cycles varying a pH value at the keratinized tissue effective to cause at least a portion of the plurality of cuticles to switch between an open state and a closed state. 
     
     
         17 . The method of  claim 1 , the keratinized tissue comprising a plurality of keratinized epidermal skin cells, at least one of the one or more treatment cycles causing a pH at the keratinized tissue to vary effective to cause at least a portion of the plurality of keratinized epidermal skin cells to be shed from the keratinized tissue. 
     
     
         18 . The method of  claim 1 , further comprising: preparing the acid-activated gas-generating composition by contacting a precursor of the acid-activated gas-generating composition with one or more of: water or a slip composition, the slip composition comprising one or more of: water, aloe vera extract, panthenol, a sugar, a nonionic surfactant, a preservative, a water soluble alkali metal halide salt, a water soluble alkali earth metal salt, an ionic surfactant, or sea trace elements. 
     
     
         19 . The method of  claim 1 , further comprising: preparing the acid composition by contacting a precursor of the acid composition with one or more of: water or a slip composition, the slip composition comprising one or more of: water, aloe vera extract, panthenol, a sugar, a nonionic surfactant, a preservative, a water soluble alkali metal halide salt, a water soluble alkali earth metal salt, an ionic surfactant, or sea trace elements. 
     
     
         20 . A kit configured for treating a keratinized tissue condition in a subject in need thereof, comprising:
 an acid-activated gas-generating composition or a precursor thereof comprised by a first reservoir;   an acid composition or a precursor thereof comprised by a second reservoir separated from the first reservoir;   instructions, the instructions comprising directions to conduct one or more treatment cycles on the keratinized tissue, each treatment cycle comprising:
 contacting the keratinized tissue with the acid-activated gas-generating composition; 
 contacting the keratinized tissue with the acid composition; and 
 allowing the acid composition and the acid-activated gas-generating composition to react effective to generate a gas at the keratinized tissue. 
   
     
     
         21 . The kit of  claim 23 , the first reservoir comprising the precursor of the acid-activated gas-generating composition, the kit further comprising:
 a slip composition comprised by a third reservoir, the slip composition comprising one or more of: water, aloe vera extract, panthenol, a sugar, a nonionic surfactant, a preservative, a water soluble alkali metal halide salt, a water soluble alkali earth metal salt, an ionic surfactant, or sea trace elements; and   instructions to combine the slip composition with the precursor of the acid-activated gas-generating composition in the first reservoir to form the acid-activated gas-generating composition.   
     
     
         22 . The kit of  claim 23 , the first reservoir comprising the precursor of the acid-activated gas-generating composition, the kit further comprising instructions to contact water to the precursor of the acid-activated gas-generating composition in the first reservoir. 
     
     
         23 . The kit of  claim 23 , the second reservoir comprising the precursor of the acid composition, the kit further comprising:
 a slip composition comprised by a third reservoir, the slip composition comprising one or more of: water, aloe vera extract, panthenol, a sugar, a nonionic surfactant, a preservative, a water soluble alkali metal halide salt, a water soluble alkali earth metal salt, an ionic surfactant, or sea trace elements; and   instructions to combine the slip composition with the precursor of the acid composition in the second reservoir to form the acid composition.   
     
     
         24 . The kit of  claim 23 , the second reservoir comprising the precursor of the acid composition, the kit further comprising instructions to contact water to the precursor of the acid composition in the second reservoir. 
     
     
         25 . The kit of  claim 23 , the instructions comprising conducting one or more treatment sessions over a period of time until the keratinized tissue condition is at least partly ameliorated, each of the one or more treatment sessions comprising conducting the one or more treatment cycles on the keratinized tissue. 
     
     
         26 . The kit of  claim 23 , the instructions comprising conducting the one or more treatment cycles to treat a keratinized tissue condition of the keratinized tissue, the keratinized tissue condition comprising one or more of: acneiform eruptions, autoinflammatory syndromes, chronic blistering, conditions of the skin appendages, dermatitis, drug or agent eruptions, infection-related, papulosquamous hyperkeratosis, palmoplantar keratodermas, pruritis, psoriasis, conditions resulting from physical factors, or ionizing radiation-induced conditions. 
     
     
         27 . The kit of  claim 23 , the instructions further comprising conducting one or more of:
 at least one treatment cycle comprising contacting the keratinized tissue with the acid-activated gas-generating composition before contacting the keratinized tissue with the acid composition;   at least one treatment cycle comprising contacting the keratinized tissue with the acid composition before contacting the keratinized tissue with the acid-activated gas-generating composition;   at least one treatment cycle comprising rinsing the keratinized tissue after allowing the acid composition and the acid-activated gas-generating composition to react effective to generate the gas at the keratinized tissue;   at least one treatment cycle comprising contacting the keratinized tissue with the acid composition after conducting the one or more treatment cycles on the keratinized tissue; or   two or more of the treatment cycles in succession on the keratinized tissue.   
     
     
         28 . The kit of  claim 23 , the instructions further comprising adjusting the keratinized tissue to between a pH of about 4.5 and a pH of about 6.5 after conducting the one or more treatment cycles on the keratinized tissue. 
     
     
         29 . The kit of  claim 23 , the instructions further comprising conducting at least one of the one or more treatment cycles effective to cause the keratinized tissue to vary in pH between an alkaline state and an acidic state. 
     
     
         30 . The kit of  claim 23 , the instructions further comprising conducting, on the keratinized tissue, the keratinized tissue comprising a plurality of cuticles, at least one of the one or more treatment cycles to vary a pH value at the keratinized tissue effective to cause at least a portion of the plurality of cuticles to switch between an open state and a closed state. 
     
     
         31 . The kit of  claim 23 , the instructions further comprising conducting, on the keratinized tissue, the keratinized tissue comprising a plurality of keratinized epidermal skin cells, at least one of the one or more treatment cycles to cause a pH at the keratinized tissue to vary effective to cause at least a portion of the plurality of keratinized epidermal skin cells to be shed from the keratinized tissue. 
     
     
         32 . The kit of  claim 23 , the acid-activated gas-generating composition or the precursor thereof comprising one or more gas generating agents comprising one or more of: an alkali metal carbonate, alkali earth metal carbonate, an alkali metal bicarbonate, an alkali earth metal bicarbonate, or carbonic acid. 
     
     
         33 . The kit of  claim 23 , the acid composition or the precursor thereof comprising an acid comprising one or more of: lactic acid, acetic acid, formic acid, citric acid, oxalic acid, phosphoric acid, succinic acid, uric acid, or an acidic ammonium salt. 
     
     
         34 . The kit of  claim 23 , the acid-activated gas-generating composition and the acid composition each independently comprising one or more of: water, aloe vera extract, panthenol, a sugar, a nonionic surfactant, a preservative, a water soluble alkali metal halide salt, a water soluble alkali earth metal salt, an ionic surfactant, a sugar, or sea trace elements 
     
     
         35 . The kit of  claim 23 , the acid activated gas generating composition comprising sodium hydrogen carbonate, a water soluble alkali metal halide salt, a water soluble alkali earth metal salt; and a sugar. 
     
     
         36 . The kit of  claim 23 , the acid composition comprising citric acid, a water soluble alkali metal halide salt, a water soluble alkali earth metal salt; and a sugar.