US2015246960A1PendingUtilityA1
Methods Of Producing A Secreted Protein
Est. expiryMay 11, 2027(~0.8 yrs left)· nominal 20-yr term from priority
C07K 16/2896C12N 9/2402C12P 21/02C12N 15/1138C12Y 302/01045C12N 2310/14C12N 2320/30C07K 2317/76C07K 16/40C07K 14/70596
44
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Claims
Abstract
The invention is directed to methods of producing a polypeptide or a variant thereof, wherein the polypeptide or variant thereof is dependent on LIMP-2 for trafficking, localization, stabilization and/or sorting of the polypeptide in the cell. In general, the methods comprise culturing a lysosomal integral membrane protein II (LIMP-2) deficient cell which expresses the polypeptide or the variant thereof under conditions in which the polypeptide or the variant thereof is produced.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . A nucleic acid molecule comprising SEQ ID NO: 1.
2 . A nucleic acid molecule that encodes an amino acid sequence comprising SEQ ID NO: 31.
3 . An isolated polypeptide having an amino acid sequence comprising SEQ ID NO: 31.
4 . An expression construct comprising SEQ ID NO: 1.
5 . A host cell comprising the expression construct of claim 4 .Join the waitlist — get patent alerts
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