Biopsy marker with in situ-generated imaging properties

Abstract

A method of marking a biopsy site within living tissue of a host includes providing a marker that incorporates biological tissue for which antibodies can be produced; inserting the marker at the biopsy site in the host; producing a specific antibody for the biological tissue that is grown and tagged with a radioactive label; injecting the specific antibody in the host, the specific antibody concentrating in and about the biological tissue to cause a concentration of the radioactive label in the vicinity of the marker; and imaging the radioactive label using a radiation detector.

1 - 29 . (canceled) 
     
     
         30 . A method of marking a biopsy site within living tissue of a host, comprising:
 providing a marker that incorporates biological tissue for which antibodies can be produced;   inserting the marker at the biopsy site in the host;   producing a specific antibody for the biological tissue that is grown and tagged with a radioactive label;   injecting the specific antibody in the host, the specific antibody concentrating in and about the biological tissue to cause a concentration of the radioactive label in the vicinity of the marker; and   imaging the radioactive label using a radiation detector.   
     
     
         31 . The method of  claim 30 , wherein the biological tissue is bovine pericardium tissue. 
     
     
         32 . The method of  claim 30 , wherein the specific antibody is a bovine tissue specific antibody. 
     
     
         33 . A method of marking a biopsy site within living tissue of a host, comprising:
 providing a marker that incorporates bovine tissue;   inserting the marker at the biopsy site in the host;   producing a bovine tissue specific antibody for the bovine tissue that is grown and tagged with a radioactive label;   injecting the bovine tissue specific antibody in the host, the bovine tissue specific antibody concentrating in and about the bovine tissue to cause a concentration of the radioactive label in the vicinity of the marker; and   imaging the concentration of the radioactive label in the vicinity of the marker using a radiation detector.   
     
     
         34 . The method of  claim 33 , wherein the bovine tissue is bovine pericardium tissue. 
     
     
         35 . A method of marking a biopsy site within living tissue of a host, comprising:
 providing a marker that incorporates biological tissue for which antibodies can be produced;   inserting the marker at the biopsy site in the host;   producing a specific antibody using a selected isotope;   injecting the specific antibody in the host, the specific antibody concentrating in and about the biological tissue to cause a concentration of the selected isotope in the vicinity of the marker; and   imaging the concentration of the selected isotope in the vicinity of the marker with externally applied radiation.   
     
     
         36 . The method of  claim 35 , wherein the biological tissue is bovine tissue and the specific antibody is a bovine tissue specific antibody. 
     
     
         37 . The method of  claim 35 , wherein the biological tissue is bovine pericardium tissue and the specific antibody is a bovine tissue specific antibody. 
     
     
         38 . The method of  claim 35 , wherein the biological tissue is bovine tissue. 
     
     
         39 . The method of  claim 35 , wherein the specific antibody is a bovine tissue specific antibody.