Methods for sample storage and device thereof

Abstract

A method of drying a biological sample disposed on a substrate is provided. The method comprises providing the substrate comprising a sample loading area and a heat source; activating the heat source for generating heat; heating the substrate at least above 65° C.; and drying the biological sample. A device for storing sample is also provided, wherein the device comprises a substrate for biological sample-storage; and a heating component that generates heat to maintain a temperature of at least above 65° C. The heating component may contain one or more reagents, wherein the reagents generate heat to maintain a temperature of at least above 65° C.

1 . A device, comprising:
 a substrate for biological sample-storage,   wherein the substrate comprises   a sample loading area; and   a heat source that generates a heat to maintain a temperature of at least above 65° C.   
     
     
         2 . The device of  claim 1  further comprising an activation component for activating the heat source. 
     
     
         3 . The device of  claim 2 , wherein the activation component comprises a slit disk, a spring, a switch, a knob, a lever or a pulling tab. 
     
     
         4 . The device of  claim 1 , wherein the substrate comprises a solid phase extraction matrix, a filtration matrix, a membrane, a foam, a paper or combinations thereof. 
     
     
         5 . The device of  claim 1 , wherein the substrate further comprises one or more cell lysis reagents, biomolecules stabilizing reagents or combinations thereof. 
     
     
         6 . The device of  claim 1 , wherein the substrate has a porous structure with pore diameters in a range between 10 nm and 1 mm. 
     
     
         7 . The device of  claim 1 , wherein the substrate has a thickness of about 0.1 mm to 10 mm. 
     
     
         8 . The device of  claim 1 , wherein the substrate is a paper comprises cell lysis reagents. 
     
     
         9 . The device of  claim 1 , wherein the heat source comprises an electrical heater, an IR heater, a reactor component comprising one or more reagents or combinations thereof. 
     
     
         10 . The device of  claim 1 , wherein the reagents generate heat to maintain a temperature of about 95° C. 
     
     
         11 . The device of  claim 1 , wherein the reagents result in an exothermic reaction, including hydration of a salt powder, oxidation of a metal, displacement of a less reactive metal, a salt forming neutralization reaction between an acid and base, or combinations thereof. 
     
     
         12 . The device of  claim 1 , further comprises one or more controllers for regulating a temperature, fluid flow, heat generation or combinations thereof. 
     
     
         13 . The device of  claim 1 , further comprises one or more temperature sensors.