Process for the preparation of c-fms kinase inhibitors

Abstract

The present invention is directed to a process for the preparation of heterocyclic derivatives of formula I wherein J, X, Z, and R 2 are as defined herein. Such compounds are useful as protein tyrosine kinase inhibitors, more particularly inhibitors of c-fms kinase.

1 - 75 . (canceled) 
     
     
         76 . A process for the preparation of a compound of formula (XX) 
       
         
           
           
               
               
           
         
         comprising 
       
       
         
           
           
               
               
           
         
       
       reacting a compound of formula (XXII) is reacted with NfsulphF, in the presence of DBU; in an organic solvent; at a temperature of from about 0° C. to about room temperature; to yield the corresponding compound of formula (XX). 
     
     
         77 . A process according to  claim 76 , wherein the NfsulphF is present in an amount of form about 1.0 molar equivalents to about 1.5 molar equivalents. 
     
     
         78 . A process according to  claim 77 , wherein the NfsulphF is present in an amount of form about 1.1 molar equivalents to about 1.3 molar equivalents. 
     
     
         79 . A process according to  claim 78 , wherein the NfsulphF is present in an amount of about 1.2 molar equivalents. 
     
     
         80 . A process according to  claim 76 , wherein the DBU is present in an amount in the range of from about 1.1 molar equivalents to about 4.0 molar equivalents. 
     
     
         81 . A process according to  claim 80 , wherein the DBU is present in an amount of from about 1.5 molar equivalents to about 2.5 molar equivalents. 
     
     
         82 . A process according to  claim 81 , wherein the DBU is present in an amount of about 2.0 molar equivalents. 
     
     
         83 . A process according to  claim 76 , wherein the organic solvent is selected from the group consisting of 2-methyl-THF, THF and toluene. 
     
     
         84 . A process according to  claim 83 , wherein the organic solvent is 2-methyl-THF. 
     
     
         85 . A process according to  claim 76 , wherein the compound of formula (XXII) is reacted with NfsulphF at a temperature of from about 0° C. to about room temperature. 
     
     
         86 . A process according to  claim 85 , wherein the compound of formula (XXII) is reacted with NfsulphF at about room temperature.