Process for producing optically active 2-alkyl-1,1,3-trialkoxycarbonylpropane

Abstract

A process for producing an optically active 2-alkyl-1,1,3-trialkoxycarbonylpropane (2), comprising a step of asymmetric hydrolysis of 2-alkyl-1,1,3-trialokoxycarbonylpropane (1) by using an enzyme capable of selectively hydrolyzing an ester moiety of either one enantiomer of 2-alkyl-1,1,3-trialkoxycarbonylpropane (1), or by using a culture of a microorganism capable of producing the enzyme or a treated object thereof.

1 - 11 . (canceled) 
     
     
         12 . A process for producing an optically active 2-alkyl-1,1,3-trialkoxycarbonylpropane of Formula (2): 
       
         
           
           
               
               
           
         
       
       wherein:
 R 1 , R 2  and R 3 , which may be the same or different, are a C1-C4 alkyl group; and 
 * represents an asymmetrical center; comprising hydrolyzing a 2-alkyl-1,1,3-trialokoxycarbonylpropane of Formula (1): 
 
       
         
           
           
               
               
           
         
       
       wherein R 1 , R 2  and R 3  are as defined above, to provide the optically active 2-alkyl-1,1,3-trialkoxycarbonylpropane of Formula (2). 
     
     
         13 . The process according to  claim 12 , wherein R 1  is methyl. 
     
     
         14 . The process according to  claim 12 , wherein R 2  is methyl. 
     
     
         15 . The process according to  claim 12 , wherein R 3  is methyl. 
     
     
         16 . The process according to  claim 12 , wherein both R 1  and R 2  are methyl. 
     
     
         17 . The process according to  claim 12 , wherein both R 2  and R 3  are methyl. 
     
     
         18 . The process according to  claim 12 , wherein R 1 , R 2  and R 3  are methyl.